对120名对屋尘和粉尘螨过敏的受试者进行的一项研究中皮肤试验、吸入试验与特异性IgE之间的相关性

Correlation between skin tests, inhalation tests and specific IgE in a study of 120 subjects allergic to house dust and Dermatophagoïdes pteronyssinus.

作者信息

Pauli G, Bessot J C, Thierry R, Lamensans A

出版信息

Clin Allergy. 1977 Jul;7(4):337-45. doi: 10.1111/j.1365-2222.1977.tb01461.x.

DOI:10.1111/j.1365-2222.1977.tb01461.x

Abstract

The radioallergosorbent test was compared with currently accepted allergy diagnostic techniques in seventy-four controls and 120 patients with a clinical history of allergy to house dust and Dermatophagoïdes pteronyssinus. The results obtained with D. pteronyssinus allergen extract show a close correlation between the size of the cutaneous reactions and the serum level of allegen-specific IgE. On the other hand, highly positive skin tests to house dust were not always correlated with a positive RAST response for house dust. Similar results were found with inhalation tests. When a purified D. pteronyssinus extract was used, a stronger relationship was observed between RAST, cutaneous and inhalation tests. It can be assumed that RAST for house dust is not of value in patients with house dust and mite allergy. Our findings indicate that the correlations between RAST results and other in vivo test results depend on the purity of the allergen extracts and the selection of patients.

摘要

在74名对照者和120名有对屋尘和粉尘螨过敏临床病史的患者中，对放射变应原吸附试验与目前公认的过敏诊断技术进行了比较。用粉尘螨变应原提取物获得的结果显示，皮肤反应的大小与变应原特异性IgE的血清水平之间密切相关。另一方面，对屋尘的皮肤试验高度阳性并不总是与屋尘的放射变应原吸附试验阳性反应相关。吸入试验也得到了类似的结果。当使用纯化的粉尘螨提取物时，在放射变应原吸附试验、皮肤试验和吸入试验之间观察到更强的相关性。可以假定，对于有屋尘和螨虫过敏的患者，屋尘的放射变应原吸附试验没有价值。我们的研究结果表明，放射变应原吸附试验结果与其他体内试验结果之间的相关性取决于变应原提取物的纯度和患者的选择。