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大鼠肾脏肾小球中组氨酸脱羧酶介导的组胺合成。

Histidine decarboxylase-mediated histamine synthesis in glomeruli from rat kidneys.

作者信息

Heald J I, Hollis T M

出版信息

Am J Physiol. 1976 May;230(5):1349-53. doi: 10.1152/ajplegacy.1976.230.5.1349.

DOI:10.1152/ajplegacy.1976.230.5.1349
PMID:5898
Abstract

Enzymatic histamine synthesis by renal glomeruli of the rat has been examined. Assays of the partially purified enzyme demonstrated a pH optimum of 6.2, a Michaelis-Menten constant of 2.4 X 10(-4) histidine, and lack of potentiation by benzene. These data thus indicate that renal glomeruli contain the histidine-specific histidine decarboxylase.

摘要

已对大鼠肾小球的组胺酶促合成进行了研究。对部分纯化的酶进行的测定表明,其最适pH值为6.2,米氏常数为2.4×10⁻⁴组氨酸,且不受苯的增强作用。因此,这些数据表明肾小球含有组氨酸特异性组氨酸脱羧酶。

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Histidine decarboxylase-mediated histamine synthesis in glomeruli from rat kidneys.大鼠肾脏肾小球中组氨酸脱羧酶介导的组胺合成。
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引用本文的文献

1
Histamine in the kidneys: what is its role in renal pathophysiology?肾脏中的组胺:它在肾脏病理生理学中的作用是什么?
Br J Pharmacol. 2020 Feb;177(3):503-515. doi: 10.1111/bph.14619. Epub 2019 Apr 15.
2
Dynamics of renal histamine in normal rat kidney and in nephrosis induced by aminonucleoside of puromycin.正常大鼠肾脏及嘌呤霉素氨基核苷诱导的肾病中肾脏组胺的动态变化
J Clin Invest. 1982 Feb;69(2):327-36. doi: 10.1172/jci110456.
3
The role of histamine receptors in the release of renin.组胺受体在肾素释放中的作用。
Br J Pharmacol. 1983 May;79(1):57-61. doi: 10.1111/j.1476-5381.1983.tb10495.x.
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Renal histamine: release by immune stimuli.肾脏组胺:由免疫刺激释放。
Agents Actions. 1986 Nov;19(3-4):141-9. doi: 10.1007/BF01966198.
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Modulation of cyclic nucleotides in islated rat glomeruli: role of histamine, carbamylcholine, parathyroid hormone, and angiotensin-II.离体大鼠肾小球中环状核苷酸的调节:组胺、氨甲酰胆碱、甲状旁腺激素及血管紧张素II的作用
J Clin Invest. 1978 Dec;62(6):1334-43. doi: 10.1172/JCI109254.