嗜铬细胞瘤大鼠血浆肾素活性及肾素释放减少。

Decreased plasma renin activity and renin release in rats with phaeochromocytoma.

Fray J C, Mayer P V

Clin Sci Mol Med. 1977 Nov;53(5):447-52. doi: 10.1042/cs0530447.

Abstract

We have examined the response of renin to chronic low and high sodium chloride intake in rats with transplanted phaeochromocytoma. 2. Phaeochromocytoma suppressed the usual elevated plasma renin activity observed during sodium deprivation. 3. Studies in isolated perfused kidneys indicated that sodium-deprived phaeochromocytoma rats released substantially less renin than sodium-deprived control rats despite an almost identical renal renin content in both sets of animals. In addition, low perfusion pressure (50 mmHg) failed to stimulate renin release in kidneys from these phaeochromocytoma rats. 4. Additional experiments demonstrated that chronic sodium chloride loading suppressed plasma renin activity, renin content and renin release in both phaeochromocytoma and control rats. Both sodium-loaded phaeochromocytoma and sodium-loaded control rats were unresponsive to low perfusion pressure. 5. We conclude that noradrenaline-secreting phaeochromocytoma impairs the response of plasma renin activity in the rat by inhibiting renin release. We also conclude that chronic sodium chloride loading has a similar effect, but the mechanisms remain to be determined.

摘要

我们研究了移植嗜铬细胞瘤大鼠对慢性低氯化钠和高氯化钠摄入的肾素反应。2. 嗜铬细胞瘤抑制了在缺钠期间通常观察到的血浆肾素活性升高。3. 对离体灌注肾脏的研究表明，缺钠的嗜铬细胞瘤大鼠释放的肾素比缺钠的对照大鼠少得多，尽管两组动物的肾脏肾素含量几乎相同。此外，低灌注压（50 mmHg）未能刺激这些嗜铬细胞瘤大鼠肾脏中的肾素释放。4. 额外的实验表明，慢性氯化钠负荷抑制了嗜铬细胞瘤大鼠和对照大鼠的血浆肾素活性、肾素含量和肾素释放。高盐负荷的嗜铬细胞瘤大鼠和高盐负荷的对照大鼠对低灌注压均无反应。5. 我们得出结论，分泌去甲肾上腺素的嗜铬细胞瘤通过抑制肾素释放损害大鼠血浆肾素活性的反应。我们还得出结论，慢性氯化钠负荷有类似作用，但机制仍有待确定。