Billing R J, Terasaki P I, Honig R, Peterson P
Lancet. 1976 Jun 26;1(7974):1365-7. doi: 10.1016/s0140-6736(76)93022-1.
60 leukaemia patients with acute mylogenous leukaemia, chronic myelocytic leukaemia, acute lymphatic leukaemia, and chronic lymphocytic leukaemia were tested for five specificities of the new B-lymphocyte alloantigenic system. Two specificities of the first B-cell locus were significantly lower in frequency than in B lymphocytes from 105 controls. B-cell group 1 was found in 18% of leukaemia patients vs. 48% of controls (p less than 0.025) and B-cell group 2 was found in 0% of leukaemia patients vs 23% of controls (p less than 0.025). Group 2 was also absent in 37 cultured lymphoblastoid lines. It is suggested that resistance to B-cell leukaemia and to Epstein-Barr virus transformation in vitro may be linked to a B-lymphocyte specificity on the first B-lymphocyte locus.
对60例患有急性髓性白血病、慢性粒细胞白血病、急性淋巴细胞白血病和慢性淋巴细胞白血病的白血病患者进行了新的B淋巴细胞同种抗原系统的五种特异性检测。第一个B细胞位点的两种特异性在频率上显著低于105名对照的B淋巴细胞。在18%的白血病患者中发现了B细胞第1组，而对照中为48%（p<0.025）；在白血病患者中未发现B细胞第2组，而对照中为23%（p<0.025）。在37个培养的淋巴母细胞系中也未发现第2组。有人提出，对B细胞白血病和体外爱泼斯坦-巴尔病毒转化的抗性可能与第一个B淋巴细胞位点上的B淋巴细胞特异性有关。
