Dickson A
Acta Haematol. 1975;54(3):143-51. doi: 10.1159/000208065.
In 54 patients with leukaemia a raised incidence of HL-A9 was noted as well as a markedly increased association between this antigen and HL-A2. This occurred most frequently in patients with chronic myeloid leukemia. As HL-A2 and HL-A9 are both antigens of the first series it has been suggested that all the predisposition to develop leukaemia is controlled by a recessive gene closely linked to the first LH-A locus and in a linkage disequilibrium with HL-A2 and HL-A9. 5 patients also showed definite changes between antigens of the same series, whilst other suffered a partial or total loss in antigenicity. Lymphocytes from 145 controls did not behave in this way, though other patients receiving radiotherapy also 'lost' antigens. So it was postulated that such changes resulted from the treatment of the disease rather than the disease itself.
在54例白血病患者中，发现HL - A9的发生率升高，并且该抗原与HL - A2之间的关联明显增加。这在慢性粒细胞白血病患者中最为常见。由于HL - A2和HL - A9都是第一系列的抗原，有人提出，所有患白血病的易感性都由一个与第一个HL - A位点紧密连锁且与HL - A2和HL - A9处于连锁不平衡状态的隐性基因控制。5例患者还表现出同一系列抗原之间的明确变化，而其他患者则出现了部分或全部抗原性丧失。145名对照者的淋巴细胞没有出现这种情况，不过其他接受放疗的患者也“丢失”了抗原。因此推测，这种变化是由疾病治疗而非疾病本身导致的。
