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Comparative fates of intravenously and orally administered aldosterone: evidence for extrahepatic formation of acid-hydrolyzable conjugate in man.

作者信息

Bledsoe T, Liddle G W, Riondel A, Island D P, Bloomfield D, Sinclair-Smith B

出版信息

J Clin Invest. 1966 Feb;45(2):264-9. doi: 10.1172/JCI105339.

DOI:10.1172/JCI105339
PMID:5901510
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC292691/
Abstract
摘要

相似文献

1
Comparative fates of intravenously and orally administered aldosterone: evidence for extrahepatic formation of acid-hydrolyzable conjugate in man.静脉注射和口服醛固酮的比较转归：人体中酸可水解共轭物肝外形成的证据。
J Clin Invest. 1966 Feb;45(2):264-9. doi: 10.1172/JCI105339.
2
[On the extrahepatic aldosterone metabolism. 3. Formation and excretion of 18-aldosterone glucuronide in the human kidney].[关于肝外醛固酮代谢。3. 人肾中18-醛固酮葡糖醛酸苷的形成与排泄]
Z Gesamte Exp Med Einschl Exp Chir. 1968 Apr 26;146(4):336-45.
3
[On the extrahepatic aldosterone metabolism. II. Plasma protein binding and renal clearance of tetrahydroaldosterone glucuronide and 18-aldosterone glucuronide in man].[关于肝外醛固酮代谢。II. 人血浆中四氢醛固酮葡萄糖醛酸苷和18-醛固酮葡萄糖醛酸苷的蛋白结合及肾清除率]
Z Gesamte Exp Med Einschl Exp Chir. 1968 Apr 26;146(4):329-35.
4
[On the extrahepatic metabolism of aldosterone. I. Production and excretion of 18-aldosteroneglucuronide in the dog kidney].[关于醛固酮的肝外代谢。I. 犬肾中18-醛固酮葡糖醛酸苷的产生与排泄]
Z Gesamte Exp Med Einschl Exp Chir. 1968;145(3):270-7.
5
Contribution to the study of the structure of the aldosterone-conjugate isolated from human urine.对从人尿中分离出的醛固酮结合物结构研究的贡献
Biochim Biophys Acta. 1965 Jul 8;104(2):515-23. doi: 10.1016/0304-4165(65)90357-0.
6
The metabolism of orally and intravenously administered labeled aldosterone in pregnant subjects.妊娠受试者口服和静脉注射标记醛固酮后的代谢情况。
J Clin Invest. 1969 Nov;47(11):2423-9. doi: 10.1172/JCI105925.
7
Studies on phenolic steroids in human subjects. XVI. Role of the kidney in the disposition of estriol.人体中酚类甾体的研究。第十六部分。肾脏在雌三醇代谢中的作用。
J Clin Endocrinol Metab. 1972 Mar;34(3):546-57. doi: 10.1210/jcem-34-3-546.
8
A comparison of the metabolism of radioactive 17-isoaldosterone and aldosterone administered intravenously and orally to normal human subjects.对正常人类受试者静脉注射和口服放射性17-异醛固酮及醛固酮后的代谢情况进行比较。
J Clin Invest. 1967 May;46(5):717-27. doi: 10.1172/JCI105572.
9
Further experimental evidence for the formation of the acid hydrolyzable conjugate of aldosterone by the kidney.肾脏形成醛固酮酸可水解共轭物的进一步实验证据。
Acta Endocrinol (Copenh). 1967 Aug;55(4):637-47. doi: 10.1530/acta.0.0550637.
10
Determination of small amounts of 18-aldosterone glucuronide in urine.尿液中痕量18-醛固酮葡萄糖醛酸苷的测定
Physiol Bohemoslov. 1971;20(4):345-52.

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Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive review.血清和尿类固醇代谢组学反映了人类类固醇的生物合成、代谢和排泄的差异：全面综述。
J Steroid Biochem Mol Biol. 2019 Nov;194:105439. doi: 10.1016/j.jsbmb.2019.105439. Epub 2019 Jul 27.
2
Renal drug metabolism in humans: the potential for drug-endobiotic interactions involving cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT).人体肾脏的药物代谢：涉及细胞色素 P450（CYP）和 UDP-葡糖醛酸基转移酶（UGT）的药物-内源性物质相互作用的潜力。
Br J Clin Pharmacol. 2013 Oct;76(4):587-602. doi: 10.1111/bcp.12086.
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Aldosterone glucuronidation by human liver and kidney microsomes and recombinant UDP-glucuronosyltransferases: inhibition by NSAIDs.人肝微粒体和肾微粒体及重组 UDP-葡糖醛酸基转移酶对醛固酮的葡糖醛酸化：非甾体抗炎药的抑制作用。
Br J Clin Pharmacol. 2009 Sep;68(3):402-12. doi: 10.1111/j.1365-2125.2009.03469.x.
4
The renal tubular handling of aldosterone and its acid-labile conjugate.醛固酮及其酸不稳定共轭物的肾小管处理
J Clin Invest. 1968 Feb;47(2):242-8. doi: 10.1172/JCI105720.
5
A comparison of the metabolism of radioactive 17-isoaldosterone and aldosterone administered intravenously and orally to normal human subjects.对正常人类受试者静脉注射和口服放射性17-异醛固酮及醛固酮后的代谢情况进行比较。
J Clin Invest. 1967 May;46(5):717-27. doi: 10.1172/JCI105572.
6
Distribution, conjugation, and excretion of labeled aldosterone in congestive heart failure and in controls with normal circulation: development and testing of a model with an analog computer.充血性心力衰竭患者及循环正常对照者体内标记醛固酮的分布、结合与排泄：模拟计算机模型的建立与测试
J Clin Invest. 1966 Aug;45(8):1302-16. doi: 10.1172/JCI105437.
7
The metabolism of orally and intravenously administered labeled aldosterone in pregnant subjects.妊娠受试者口服和静脉注射标记醛固酮后的代谢情况。
J Clin Invest. 1969 Nov;47(11):2423-9. doi: 10.1172/JCI105925.
8
[Secretion, plasma concentration, distribution, metabolism and excretion of aldosterone in healthy and sick subjects].[健康和患病受试者中醛固酮的分泌、血浆浓度、分布、代谢及排泄]
Klin Wochenschr. 1968 Jul 15;46(14):741-51. doi: 10.1007/BF01745487.
9
[Shortened biological half-life period of 1,2-3H-aldosterone in 3 nephretomized patients].[3例肾切除患者中1,2 - 3H - 醛固酮生物半衰期缩短]
Klin Wochenschr. 1968 Jan 1;46(1):47-9. doi: 10.1007/BF01725303.
10
Stimulation and suppression of aldosterone in plasma of normal man and in primary aldosteronism.正常人和原发性醛固酮增多症患者血浆中醛固酮的刺激与抑制
J Clin Invest. 1969 Jul;48(7):1230-6. doi: 10.1172/JCI106087.

本文引用的文献

1
Double isotope derivative assay of aldosterone in biological extracts.生物提取物中醛固酮的双同位素衍生物测定法。
J Biol Chem. 1960 Jun;235:1639-48.
2
Aldosterone metabolism in liver disease.肝脏疾病中的醛固酮代谢
Acta Endocrinol (Copenh). 1960 Feb;33:168-74. doi: 10.1530/acta.0.xxxiii0168.
3
[RENAL CLEARANCE OF ALDOSTERONE AND ITS METABOLITE IN MAN].[人体中醛固酮及其代谢产物的肾脏清除率]
Acta Endocrinol (Copenh). 1965 Aug;49:510-24.
4
CONJUGATION OF 1,2-3H-ALDOSTERONE IN HUMAN LIVER AND KIDNEYS AND RENAL EXTRACTION OF ALDOSTERONE AND LABELED CONJUGATES FROM BLOOD PLASMA.人肝脏和肾脏中1,2-³H-醛固酮的结合以及醛固酮和标记结合物从血浆中的肾脏提取
J Clin Endocrinol Metab. 1965 May;25:628-38. doi: 10.1210/jcem-25-5-628.
5
SPLANCHNIC EXTRACTION AND CLEARANCE OF ALDOSTERONE IN SUBJECTS WITH MINIMAL AND MARKED CARDIAC DYSFUNCTION.轻度和重度心功能不全患者醛固酮的内脏提取与清除
J Clin Endocrinol Metab. 1965 Feb;25:219-28. doi: 10.1210/jcem-25-2-219.
6
PURIFICATION, PARTIAL CHARACTERIZATION AND METABOLISM OF AN ACID LABILE CONJUGATE OF ALDOSTERONE.醛固酮酸不稳定结合物的纯化、部分特性鉴定及代谢
J Clin Endocrinol Metab. 1964 Nov;24:1110-24. doi: 10.1210/jcem-24-11-1110.
7
MODIFICATION OF ALDOSTERONE SECRETION AND ELECTROLYTE EXCRETION IN MAN BY A CHEMICAL INHIBITOR OF 18-OXIDATION.
J Clin Endocrinol Metab. 1964 Aug;24:740-6. doi: 10.1210/jcem-24-8-740.
8
ALDOSTERONE SECRETION AND METABOLISM IN HYPERTHYROIDISM AND MYXEDEMA.
J Clin Endocrinol Metab. 1963 Sep;23:873-80. doi: 10.1210/jcem-23-9-873.
9
The metabolism of aldosterone. II.
Acta Endocrinol (Copenh). 1962 Jan;39:87-102. doi: 10.1530/acta.0.0390087.
10
The metabolism of aldosterone in normal subjects and in patients with hepatic cirrhosis.正常受试者及肝硬化患者体内醛固酮的代谢
J Clin Invest. 1962 Aug;41(8):1672-80. doi: 10.1172/JCI104624.