Ianev K, Kolareva R, Chalukova G, Popova N, Delibasheva A
Eksp Med Morfol. 1977;16(4):223-6.
On rats with experimental hypertension by method of Selye, modified by Kolarova, distributed in two groups--treated by obsidan and untreated, the following parameters on the 1st and the 3rd month after the operation were studied: pH, BB, SB, AB, BE, PaCO2, TCO2, PaO2, and SaO2. In the hypertonic animals we establish a decompensated metabolic acidosis on the 1st month and a metabolic acidosis with a marked respiratory compensation on the 3rd month. The hypertonic animals, treated by obsidan, demonstrate a sharp tendency to normalise the parameters of the acid-base status on the 1st month and normal values on the 3rd. The protective obsidan effect observed on the hypertonic rat we discuss as a result of metabolic and functional influences of the beta-adrenergic blockers.
通过科拉罗娃改良的塞利方法使大鼠患实验性高血压，将其分为两组——用黑曜石治疗组和未治疗组，研究术后第1个月和第3个月的以下参数：pH值、缓冲碱（BB）、标准碳酸氢盐（SB）、实际碳酸氢盐（AB）、碱剩余（BE）、动脉血二氧化碳分压（PaCO2）、总二氧化碳量（TCO2）、动脉血氧分压（PaO2）和动脉血氧饱和度（SaO2）。在高血压动物中，我们发现在第1个月出现失代偿性代谢性酸中毒，在第3个月出现伴有明显呼吸代偿的代谢性酸中毒。用黑曜石治疗的高血压动物在第1个月显示出酸碱状态参数急剧趋向正常化的趋势，在第3个月显示出正常值。我们将在高血压大鼠身上观察到的黑曜石的保护作用作为β-肾上腺素能阻滞剂的代谢和功能影响的结果进行讨论。
