组胺对大鼠纹状体多巴胺代谢的直接或间接作用？
Direct or indirect action of histamine on dopamine metabolism in the rat striatum?
作者信息
Nowak J Z, Pilc A
出版信息
Eur J Pharmacol. 1977 Nov 15;46(2):171-5. doi: 10.1016/0014-2999(77)90253-9.
Intraventricular administration of 500 microgram of 2-pyridylethylamine, an agonist of the histamine (Hi) H1-receptor, produced a 20% increase of striatal HVA in the rat while the Hi H2-receptor agonist 4-methylhistamine had no influence on HVA and DOPAC levels. L-Histidine (1.5 g/kg) or amodiaquine (60 mg/kg) given i.p. increased HVA and DOPAC levels to the same extent as did pyridylethylamine. Histidine combined with tremorine had an additive effect with respect to the increase of DA acidic metabolites while mepyramine slightly attenuated the tremorine-induced rise of HVA.
向大鼠脑室内注射500微克组胺（Hi）H1受体激动剂2-吡啶乙胺，可使纹状体高香草酸（HVA）增加20%，而Hi H2受体激动剂4-甲基组胺对HVA和3,4-二羟基苯乙酸（DOPAC）水平无影响。腹腔注射L-组氨酸（1.5 g/kg）或阿莫地喹（60 mg/kg）使HVA和DOPAC水平升高的程度与吡啶乙胺相同。组氨酸与震颤素联用对多巴胺酸性代谢产物的增加具有相加作用，而美吡拉敏可略微减弱震颤素诱导的HVA升高。
Zotero 插件