Broch O J
Eur J Pharmacol. 1976 Sep;39(1):33-40. doi: 10.1016/0014-2999(76)90110-2.
The two dopamine metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were measured in corpus striatum and hippocampus in rats after an intracerebroventricular injection of DOPAC or HVA. Probenecid 200 mg/kg i.p. increased the concentration of HVA by the same factor in both control animals and animals treated with HVA. Probenecid had no effect on the DOPAC concentration in control animals or in animals treated with DOPAC. After DOPAC intraventricularly some increase in the HVA concentration could be seen. Pargyline 75 mg/kg was given i.m. and the decline of HVA and DOPAC in corpus striatum was compared in animals with or without probenecid treatment (200 mg/kg i.p.). In the control animals DOPAC declined more rapidly than did HVA. In the probenecid-treated animals there was no change in the DOPAC curve while the HVA showed a slower elimination but still with an exponential curve. The conclusion is drawn that there is an active mechanism for the excretion of DOPAC which is not identical with the excretion mechanism for HVA. A considerable part of the dopamine is directly deaminated to DOPAC in vivo and some of this DOPAC is probably O-methylated to HVA.
在大鼠脑室内注射3,4 - 二羟基苯乙酸（DOPAC）或高香草酸（HVA）后，测定纹状体和海马体中的两种多巴胺代谢产物DOPAC和HVA。腹腔注射200mg/kg丙磺舒，可使对照动物和接受HVA治疗的动物体内HVA浓度以相同倍数增加。丙磺舒对对照动物或接受DOPAC治疗的动物体内DOPAC浓度无影响。脑室内注射DOPAC后，可观察到HVA浓度有所增加。肌肉注射75mg/kg的帕吉林，并比较了有无丙磺舒治疗（腹腔注射200mg/kg）的动物纹状体中HVA和DOPAC的下降情况。在对照动物中，DOPAC的下降速度比HVA快。在丙磺舒治疗的动物中，DOPAC曲线无变化，而HVA的消除速度较慢，但仍呈指数曲线。由此得出结论，存在一种与HVA排泄机制不同的DOPAC排泄的主动机制。相当一部分多巴胺在体内直接脱氨基生成DOPAC，其中一些DOPAC可能经O - 甲基化生成HVA。
