对健康志愿者经口和经鼻急性暴露于二氧化硫后肺血流阻力变化的比较。
A comparison of changes in pulmonary flow resistance in healthy volunteers acutely exposed to SO-2 by mouth and by nose.
作者信息
Speizer F E, Frank N R
出版信息
Br J Ind Med. 1966 Jan;23(1):75-9. doi: 10.1136/oem.23.1.75.
On separate occasions, healthy male volunteers were exposed either by nose or by mouth to one of two concentrations of sulphur dioxide, 15 and 28 p.p.m. Exposure to SO lasted 10 minutes. Pulmonary flow resistance (R1) was measured by the oesophageal catheter method, and the lung volume was measured by a modification of the gas-compression method; when SO was administered by nose, nasal flow resistance (Rn) was measured by means of a catheter placed in the posterior pharynx. The increase in R1 was greater when SO was administered by mouth than when it was administered by nose. Similarly, irritative symptoms of the posterior pharynx and chest were more common during exposure by mouth. These findings suggest that the mouth is less effective than the nose as an absorptive surface for SO.
在不同的场合，健康男性志愿者通过鼻子或嘴巴接触两种浓度（15 ppm和28 ppm）的二氧化硫中的一种。接触二氧化硫持续10分钟。用食管导管法测量肺血流阻力（R1），并通过改良的气体压缩法测量肺容积；当通过鼻子给予二氧化硫时，通过放置在咽后部的导管测量鼻血流阻力（Rn）。经口给予二氧化硫时R1的增加幅度大于经鼻给予时。同样，经口接触期间咽后部和胸部的刺激症状更常见。这些发现表明，作为二氧化硫的吸收表面，口腔的效率低于鼻子。
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