McJilton C E, Frank R, Charlson R J
Am Rev Respir Dis. 1976 Feb;113(2):163-9. doi: 10.1164/arrd.1976.113.2.163.
Lightly anesthetized guinea pigs were exposed to 1 ppm of sulfur dioxide (SO2) and 1 mg per m3 of sodium chloride aerosol, individually and in combination, at low and high relative humidities. At low relative humidity (less than 40 per cent) the aerosol was a crystal, at high relative humidity (greater than 80 per cent) a droplet. Exposures lasted one hour. Changes in pulmonary mechanical function characterized by an increase in flow resistance and decrease in compliance were seen only when the mixture was administered at high relative humidity. The effect is ascribed to absorption of the highly soluble SO2 into the droplet before inhalation.
将轻度麻醉的豚鼠分别或联合暴露于1 ppm的二氧化硫（SO2）和每立方米1毫克的氯化钠气雾剂中，相对湿度分高、低两种情况。在低相对湿度（低于40%）时，气雾剂为晶体；在高相对湿度（高于80%）时，气雾剂为液滴。暴露持续1小时。仅当混合物在高相对湿度下给药时，才观察到以气流阻力增加和顺应性降低为特征的肺功能变化。这种效应归因于高溶解性的SO2在吸入前被吸收到液滴中。
