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β-肾上腺素能刺激和腺苷对豚鼠离体左心房频率-张力关系的相反影响。

The opposed influences of beta-adrenergic stimulation and adenosine on the frequency-force relationship of isolated left atria of guinea-pigs.

作者信息

Hilgemann D, Englert R, Mensing H J

出版信息

Experientia. 1977 Dec 15;33(12):1629-31. doi: 10.1007/BF01934040.

DOI:10.1007/BF01934040
PMID:590458
Abstract

The normal frequency-force relationship of left guinea-pig atria can be largely suspended when strong beta-adrenergic stimulation by orciprenaline is antagonized by the negative inotropic effect of adenosine, so that contraction amplitude is nearly equal at an intermediate level over a wide range of stimulation rates. Curves obtained with new method for recording continuous frequency-force loops are presented.

摘要

当奥西那林引起的强烈β-肾上腺素能刺激被腺苷的负性肌力作用拮抗时,豚鼠左心房正常的频率-力关系可在很大程度上被消除,从而在很宽的刺激频率范围内,收缩幅度在中间水平几乎相等。本文展示了用记录连续频率-力环的新方法所获得的曲线。

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1
The opposed influences of beta-adrenergic stimulation and adenosine on the frequency-force relationship of isolated left atria of guinea-pigs.β-肾上腺素能刺激和腺苷对豚鼠离体左心房频率-张力关系的相反影响。
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The effect of epinephrine on adenosine 3', 5'-phosphate levels in the isolated perfused rat heart.肾上腺素对离体灌注大鼠心脏中3',5'-磷酸腺苷水平的影响。
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6
Potency and selectivity in vitro of compounds related to isoprenaline and orciprenaline on beta-adrenoceptors in the guinea-pig.豚鼠体内与异丙肾上腺素和奥西那林相关的化合物对β-肾上腺素能受体的体外效力和选择性
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7
The continuous and simultaneous measurement of O2-consumption, rate of decarboxylation of 14C-substrates and the performance of spontaneously-beating isolated heart atria of guinea pigs.对豚鼠自发性搏动的离体心房进行氧气消耗、14C底物脱羧速率的连续同步测量。
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8
The regulation of the calcium conductance of cardiac muscle by adrenaline.肾上腺素对心肌钙电导的调节
J Physiol. 1977 Jan;264(1):49-62. doi: 10.1113/jphysiol.1977.sp011657.
9
Effect of papaverine on the frequency-force relationship in guinea-pig left atria.罂粟碱对豚鼠左心房频率-张力关系的影响。
Eur J Pharmacol. 1977 Jan 21;41(2):123-32. doi: 10.1016/0014-2999(77)90201-1.
10
Effects of adenosine and related compounds on adenylate cyclase and cyclic AMP levels in smooth muscle.
Eur J Pharmacol. 1977 Jan 21;41(2):193-203. doi: 10.1016/0014-2999(77)90208-4.