Papanicolaou N, Lefkos N, Massourides E, Marketos S, Papavassiliou J, Bariety J, Milliez P
Experientia. 1977 Dec 15;33(12):1632-4. doi: 10.1007/BF01934042.
Aldosterone injected i.m. decreased the release of renomedullary PGEs and the index (urinary Na/K ratio) in conscious normotensive intact and adrenalectomized rats. Coadministration of spironolactone increased the release of PGEs as well as the index (urinary Na/K ratio). The effect of spironolactone was partly inhibited by aspirin injected in a ratio 5:1 (aspirin:spironolactone), and effect which could be reversed by the infusion of a synthetic prostaglandin (PGA2) in a subhypotensive dose.
肌肉注射醛固酮可降低清醒正常血压的完整大鼠和肾上腺切除大鼠的肾髓质前列腺素E的释放以及指标（尿钠/钾比值）。同时给予螺内酯可增加前列腺素E的释放以及指标（尿钠/钾比值）。以5:1（阿司匹林：螺内酯）的比例注射阿司匹林可部分抑制螺内酯的作用，而这种作用可通过输注亚降压剂量的合成前列腺素（PGA2）来逆转。
