皮质类固醇对前列腺素生物合成的抑制作用。
Inhibition of prostaglandin biosynthesis by corticosteroids.
作者信息
Greaves M W, McDonald-Gibson W
出版信息
Br Med J. 1972 Apr 8;2(5805):83-4. doi: 10.1136/bmj.2.5805.83.
Abstract
Since prostaglandins have been consistently recovered from a wide range of inflammatory reactions, including cutaneous inflammation, we have studied the effect of the anti-inflammatory corticosteroids hydrocortisone and fluocinolone on in-vitro biosynthesis of prostaglandins by skin. Skin homogenates synthesized prostaglandins E(2) and F(2)alpha in the presence of an excess of arachidonic acid substrate. Inhibition of biosynthesis of both these prostaglandins by corticosteroids was demonstrated. Since several members of the prostaglandin group of agents can reproduce all the cardinal features of inflammation and are found in a wide range of inflammatory reactions it is concluded that at least part of the anti-inflammatory properties of corticosteroids is due to inhibition of prostaglandin biosynthesis.
摘要
由于前列腺素一直能从包括皮肤炎症在内的多种炎症反应中检测到，我们研究了抗炎皮质类固醇氢化可的松和氟轻松对皮肤前列腺素体外生物合成的影响。皮肤匀浆在过量花生四烯酸底物存在的情况下合成前列腺素E(2)和F(2)α。已证实皮质类固醇对这两种前列腺素的生物合成有抑制作用。由于前列腺素类药物中的几种成员能够重现炎症的所有主要特征，并且在多种炎症反应中都能发现，因此得出结论，皮质类固醇的抗炎特性至少部分归因于对前列腺素生物合成的抑制。
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