[Influence of adaptation of hypoxia on the relationship between tissue respiration, temperature and oxygen tension in vitro].

The effect of adaptation to hypoxia on rat tissue respiration at different pO2 and temperature in vitro was studied. The temperature coefficient Q10 and the Michaelis constant Km for oxygen were estimated. The tissue sensitivity to low pO2 and low temperature obviously decreased while the tissue affinity for oxygen and the direct temperature dependence on Km increased in animals adapted to hypoxia. A functional interrelationship between adaptational changes of Q10 and Km of tissue respiration in different organs was revealed. The data obtained suggest participation of cellular oxidation changes in adaptive increase of oxygen affinity.