Ibraimova G I
Aviakosm Ekolog Med. 1997;31(2):32-7.
Experimental studies of the dynamics of energy exchange in tissues of the rats' visceral organs (brain, heart, liver, and kidney) shortly after hypoxic stimulation displayed substantial variations in the respiratory activity of visceral tissues, and Km for oxygen at the start of the follow-on reaction (24 h, 72 h, and 120 h) which subsided later on (240 h and 360 h). These were in concert with a gross decline in the intensity of visceral tissue breathing at the initial oxygen pressure in vitro and a rise at critical pO2, a decrease in the affinity of cardiac, hepatic and renal tissues for oxygen at the onset of the follow-on reaction and an increase in the affinity at subsequent time points. Throughout the period of observation, high affinity for oxygen was observed in cerebral tissues. Combination of alpha-tocopherol and the hypoxic stimulus substantially suppressed the respiratory activity in all the visceral tissues of rats at the initial oxygen pressure and in the liver and kidney, at critical pO2. Increased utilization of the low pressure oxygen was observed in the brain and the heart. More pronounced changes in tissue affinity for oxygen were revealed in the heart and the liver, and least pronounced, in the brain and the kidney. A conclusion is drawn that alpha-tocopherol can strongly influence moderation of the stressful factor on the level of tissue homogenates.
对大鼠内脏器官（脑、心脏、肝脏和肾脏）组织在缺氧刺激后不久的能量交换动力学进行的实验研究表明，内脏组织的呼吸活动存在显著变化，后续反应开始时（24小时、72小时和120小时）氧气的米氏常数（Km）随后下降（240小时和360小时）。这些变化与体外初始氧压下内脏组织呼吸强度的大幅下降以及临界氧分压时的上升相一致，与后续反应开始时心脏、肝脏和肾脏组织对氧气的亲和力降低以及随后时间点的亲和力增加相一致。在整个观察期间，脑组织对氧气具有高亲和力。α-生育酚与缺氧刺激的联合作用在初始氧压下显著抑制了大鼠所有内脏组织的呼吸活动，在肝脏和肾脏中，在临界氧分压下也有抑制作用。在脑和心脏中观察到对低压氧的利用增加。在心脏和肝脏中发现组织对氧气的亲和力变化更为明显，而在脑和肾脏中最不明显。得出的结论是，α-生育酚可以强烈影响应激因素对组织匀浆水平的调节。
