高淀粉酶血症慢性胰腺炎患者的血清淀粉酶同工酶

Serum amylase isozymes in patients with chronic pancreatitis with hyperamylasemia.

作者信息

Wakabayashi A, Saeki M, Mori R, Oshiba S

出版信息

Gastroenterol Jpn. 1977;12(4):269-74. doi: 10.1007/BF02776794.

Abstract

In order to clarify the relationship between hyperamylasemia and clinical states in chronic pancreatitis, serum amylase isozymes were studied in 39 cases of chronic pancreatitis including 13 cases of alcoholic pancreatitis. Hyperamylasemia in chronic pancreatitis is generally due to high pancreatic type isoamylase (P-amylase) activity in acute exacerbation, sometimes accompanied by a transient elevation in salivary type isoamylase (S-amylase). On remission, however, hyperamylasemia due to high S-amylase activity has been found. These were cases of advanced alcoholic pancreatitis, which exhibited a characteristic pattern of low serum P-amylase and high serum S-amylase activities while the clearance ratio (Cam/Ccr) was normal despite high S-amylase activity. It should be noted that hyperamylasemia in chronic pancreatitis may be caused by high S-amylase activity in addition to high P-amylase activity, especially in alcoholic pancreatitis.

摘要

为阐明慢性胰腺炎患者高淀粉酶血症与临床状态之间的关系，我们对39例慢性胰腺炎患者（包括13例酒精性胰腺炎患者）的血清淀粉酶同工酶进行了研究。慢性胰腺炎患者的高淀粉酶血症通常是由于急性发作时胰腺型同工淀粉酶（P-淀粉酶）活性升高所致，有时还伴有唾液型同工淀粉酶（S-淀粉酶）短暂升高。然而，在病情缓解期，也发现了由于S-淀粉酶活性升高导致的高淀粉酶血症。这些病例为晚期酒精性胰腺炎，其特征为血清P-淀粉酶活性低、血清S-淀粉酶活性高，尽管S-淀粉酶活性高，但清除率（Cam/Ccr）正常。应当指出，慢性胰腺炎患者的高淀粉酶血症除了P-淀粉酶活性升高外，还可能由S-淀粉酶活性升高引起，尤其是在酒精性胰腺炎中。