Speakman J S, Mortimer C B, Briant T D, Ezrin C, Lougheed W M, Clarke W T
Can Med Assoc J. 1966 Mar 26;94(13):627-35.
Pituitary ablation was performed on 26 patients with advanced diabetic retinopathy by pituitary stalk section (nine patients) or transphenoidal hypophysectomy (17 patients). After a latent period varying from six to 12 months, retinal hemorrhages disappeared, vitreous hemorrhages stopped and new vessels regressed. Eight of 10 patients followed up for more than a year had a complete remission, although in one of two patients whose ablation was incomplete the retinopathy remained active. Preoperative visual acuity levels were preserved in 47 of 50 eyes of patients followed up for a mean period of 12 months. Three patients have died, two from causes related to their operation. Twenty of the survivors have continued in their usual occupation. Pituitary ablation is effective in preventing the progressive visual deterioration usually associated with advanced diabetic retinopathy.
对26例晚期糖尿病性视网膜病变患者进行了垂体切除，其中9例采用垂体柄切断术，17例采用经蝶窦垂体切除术。经过6至12个月不等的潜伏期后，视网膜出血消失，玻璃体积血停止，新生血管消退。随访超过一年的10例患者中有8例完全缓解，尽管在两例垂体切除不完全的患者中，有一例视网膜病变仍处于活动期。随访平均12个月的患者中，50只眼中有47只眼的术前视力水平得以保留。3例患者死亡，2例死于与手术相关的原因。20名幸存者继续从事他们的日常工作。垂体切除对于预防通常与晚期糖尿病性视网膜病变相关的进行性视力恶化有效。
