Deller J J, Di Raimondo V C, Grodsky G M, Forsham P H
Calif Med. 1966 Jan;104(1):1-5.
The availability of a sensitive assay for human growth hormone has made it possible to directly measure the effects of various agents purported to alter growth patterns. Acromegalic patients present a special problem both in early diagnosis and in therapy. Being able to measure growth hormone in these patients provides an accurate index of activity and a precise measure of therapeutic effectiveness. In an attempt to determine whether a pituitary block of growth hormone secretion is feasible in this condition, a study was made of the effects of estrogen, androgen and glucocorticoid administration on growth hormone response to a standard insulin tolerance test in a patient with active acromegaly. In the dosage schedules used in this study, it was not possible to suppress either basal growth hormone secretion or blunt its responsiveness to the normal physiologic stimulus of hypoglycemia.
一种用于检测人生长激素的灵敏测定方法的出现，使得直接测量各种据称能改变生长模式的药物的效果成为可能。肢端肥大症患者在早期诊断和治疗方面都存在特殊问题。能够测量这些患者体内的生长激素，可为疾病活动提供准确指标，并精确衡量治疗效果。为了确定在这种情况下垂体对生长激素分泌的阻滞是否可行，对一名活动性肢端肥大症患者进行了一项研究，观察给予雌激素、雄激素和糖皮质激素对其生长激素对标准胰岛素耐量试验反应的影响。在本研究使用的给药方案中，无法抑制基础生长激素分泌，也无法减弱其对低血糖正常生理刺激的反应性。
