免疫能力：全身X射线照射及特定淋巴组织屏蔽所致的改变

Immunological competence: alteration by whole body x-irradiation and shielding of selected lymphoid tissues.

作者信息

Miller J

出版信息

Science. 1966 Mar 18;151(3716):1395-7. doi: 10.1126/science.151.3716.1395.

DOI:10.1126/science.151.3716.1395

Abstract

The spleen and thymus of 6-week-old mice contain similar numbers of lymphoid cells. A lethal dose of x-irradiation given to animials whose thymus, midgut, or hindlimbs were shielded at the same time resulted in permanent acceptance of allografts, while a similar dose given to spleen-shielded mice so irradiated resulted in a normal rejection pattern. The return of immunological competence was related to the state of the lymphoid organs with different types of shielding.

摘要

6周龄小鼠的脾脏和胸腺含有数量相似的淋巴细胞。对同时屏蔽胸腺、中肠或后肢的动物给予致死剂量的X射线照射，会导致对同种异体移植物的永久接受，而对脾脏屏蔽的受照小鼠给予相似剂量的照射，则会导致正常的排斥反应模式。免疫能力的恢复与不同屏蔽类型的淋巴器官状态有关。