Kreulen D L, Fredericks C M, Anderson G F
Invest Urol. 1977 Nov;15(3):245-51.
Studies of the ureteral response to changes in intravesical pressure (IP) have been conducted by surgically altering the neural and hydrodynamic integrity of canine ureters. Ureteral function was assessed by acute and chronic recordings of ongoing electrical activity. Intact control ureters responded (acute to 56 per cent; chronic to 83 per cent) to elevated IP with immediate increases and to decreases in IP with slowing or cessation of activity. Acute ureteral ligation mimicked the effects of increased IP, except the responses were much slower. Ureterotomy and the resultant extravasation of urine did not alter the ureteral response. Disruption of renal nerves, whether by selective sectioning or by nephrectomy, was associated with exaggerated ureteral frequency responses which were delayed in onset. Ureters lacking neural connections with the bladder responded with bursts of multiple spikes and increases in the force of peristalsis. These observations are discussed in terms of the myogenic and neurogenic control of ureteral peristalsis.
通过手术改变犬输尿管的神经和流体动力学完整性，对输尿管对膀胱内压（IP）变化的反应进行了研究。通过对持续电活动的急性和慢性记录来评估输尿管功能。完整的对照输尿管对升高的IP有反应（急性反应为56%；慢性反应为83%），表现为活动立即增加，对IP降低则表现为活动减慢或停止。急性输尿管结扎模拟了IP升高的影响，但反应要慢得多。输尿管切开术及由此导致的尿液外渗并未改变输尿管的反应。肾神经的破坏，无论是通过选择性切断还是肾切除术，都与输尿管频率反应的过度增强有关，且反应延迟出现。与膀胱缺乏神经连接的输尿管表现为多个尖峰的爆发和蠕动力量的增加。根据输尿管蠕动的肌源性和神经源性控制对这些观察结果进行了讨论。
