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The measured extracellular space of the taenia coli is large when small ions or molecules are used for the determination, and small when large molecules are used, even with identical experimental procedures.2. Extracellular hyaluronic acid has been detected histologically. It is apparently reduced by hyaluronidase.3. The extracellular inulin space increases after the tissue has been pretreated with hyaluronidase, although the ionic composition and wet weight are unchanged.4. It is suggested that the hyaluronic acid prevents the free entry of macromolecules such as inulin into the extracellular space by steric hindrance. Monatomic ions such as Na(+), Li(+), Cl(-), Ca(2+) therefore have a larger extracellular space available than is calculated on the basis of the inulin space.5. A slight shrinkage of the muscle cells can be detected when the incubation period is prolonged.

当使用小离子或小分子进行测定时，结肠带测得的细胞外间隙较大；而使用大分子进行测定时，即使实验步骤相同，细胞外间隙也较小。
已通过组织学方法检测到细胞外透明质酸。它显然会被透明质酸酶降解。
用透明质酸酶预处理组织后，细胞外菊粉间隙增加，尽管离子组成和湿重未变。
有人提出，透明质酸通过空间位阻作用阻止诸如菊粉等大分子自由进入细胞外间隙。因此，诸如Na(+)、Li(+)、Cl(-)、Ca(2+)等单原子离子具有比根据菊粉间隙计算得出的更大的可用细胞外间隙。
当孵育期延长时，可以检测到肌肉细胞略有收缩。

The measured extracellular space of the taenia coli is large when small ions or molecules are used for the determination, and small when large molecules are used, even with identical experimental procedures.2. Extracellular hyaluronic acid has been detected histologically. It is apparently reduced by hyaluronidase.3. The extracellular inulin space increases after the tissue has been pretreated with hyaluronidase, although the ionic composition and wet weight are unchanged.4. It is suggested that the hyaluronic acid prevents the free entry of macromolecules such as inulin into the extracellular space by steric hindrance. Monatomic ions such as Na(+), Li(+), Cl(-), Ca(2+) therefore have a larger extracellular space available than is calculated on the basis of the inulin space.5. A slight shrinkage of the muscle cells can be detected when the incubation period is prolonged.

当使用小离子或小分子进行测定时，结肠带测得的细胞外间隙较大；而使用大分子进行测定时，即使实验步骤相同，细胞外间隙也较小。
已通过组织学方法检测到细胞外透明质酸。它显然会被透明质酸酶降解。
用透明质酸酶预处理组织后，细胞外菊粉间隙增加，尽管离子组成和湿重未变。
有人提出，透明质酸通过空间位阻作用阻止诸如菊粉等大分子自由进入细胞外间隙。因此，诸如Na(+)、Li(+)、Cl(-)、Ca(2+)等单原子离子具有比根据菊粉间隙计算得出的更大的可用细胞外间隙。
当孵育期延长时，可以检测到肌肉细胞略有收缩。

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