Cope G H
J Anat. 1977 Nov;124(Pt 2):323-33.
A stereological analysis of the mitochondrial compartment of the rabbit parotid gland has been carried out before and after isoprenaline-induced degranulation. Normally, mitochondria constitute about 5% of acinar cell volume, 6% of intercalcate duct cell volume and 16% of striated duct cell volume. The ratio of inner electron transport membrane to outer limiting membrane is in the range 2.3:1. Two hours after the induction of secretion by isoprenaline a significant (P less than 0.10) increase in the volume fraction of mitochondria in acinar and intercalated duct cells was noted and this may reflect increased oxidative phosphorylation at this time. Other parameters measured suggest that there is some rounding up of mitochondria Another significant feature was an increase in the number of damaged mitochondrial profiles (+80% to +250%, P less than 0.05) after isoprenaline treatment. This finding is discussed in the context of changes in mitochondrial enzyme levels which have been reported in similar situations.
在异丙肾上腺素诱导腮腺脱颗粒前后，对兔腮腺线粒体区室进行了体视学分析。正常情况下，线粒体在腺泡细胞体积中约占5%，闰管细胞体积中占6%，纹状管细胞体积中占16%。线粒体内电子传递膜与外限制膜的比例在2.3:1范围内。用异丙肾上腺素诱导分泌两小时后，观察到腺泡细胞和闰管细胞中线粒体体积分数显著增加（P<0.10），这可能反映了此时氧化磷酸化增加。所测量的其他参数表明线粒体有一定程度的变圆。另一个显著特征是异丙肾上腺素处理后受损线粒体轮廓数量增加（+80%至+250%，P<0.05）。这一发现结合类似情况下报道的线粒体酶水平变化进行了讨论。
