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从天冬氨酰葡糖胺尿症(AGU)患者尿液中分离出的两种糖天冬酰胺的结构

Structure of two glycoasparagines isolated from the urine of patients with aspartylglycosylaminuria (AGU).

作者信息

Sugahara K, Akasaki M, Funakoshi I, Aula P, Yamashina I

出版信息

J Biochem. 1977 Nov;82(5):1499-501. doi: 10.1093/oxfordjournals.jbchem.a131841.

DOI:10.1093/oxfordjournals.jbchem.a131841
PMID:591515
Abstract

The structures of two glycoasparagines composed of one mole each of N-acetylneuraminic acid, galactose, N-acetylglucosamine, and asparagine were determined by periodate oxidation, enzymatic degradation, and methylation analysis. The structures were NANAalpha2 leads to 3Galbeta1 leads to 4GlcNAcbeta leads to Asn and NANAalpha2 leads to 6Galbeta1 leads to 4GlcNAcbeta leads to Asn, respectively.

摘要

通过高碘酸盐氧化、酶促降解和甲基化分析确定了两种糖天冬酰胺的结构,每种糖天冬酰胺由一摩尔的N-乙酰神经氨酸、半乳糖、N-乙酰葡糖胺和天冬酰胺组成。其结构分别为NANAα2→3Galβ1→4GlcNAcβ→Asn和NANAα2→6Galβ1→4GlcNAcβ→Asn。

相似文献

1
Structure of two glycoasparagines isolated from the urine of patients with aspartylglycosylaminuria (AGU).从天冬氨酰葡糖胺尿症(AGU)患者尿液中分离出的两种糖天冬酰胺的结构
J Biochem. 1977 Nov;82(5):1499-501. doi: 10.1093/oxfordjournals.jbchem.a131841.
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Characterization of one neutral and two acidic glycoasparagines isolated from the urine of patients with aspartylglycosylaminuria (AGU).从天冬氨酰葡糖胺尿症(AGU)患者尿液中分离出的一种中性和两种酸性糖天冬酰胺的表征。
J Biochem. 1976 Aug;80(2):195-201. doi: 10.1093/oxfordjournals.jbchem.a131264.
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Characterization of two glycoasparagines isolated from the urine of patients with aspartylglycosylaminuria (AGU).从天冬氨酰葡糖胺尿症(AGU)患者尿液中分离出的两种糖天冬酰胺的特性分析。
J Biochem. 1975 Oct;78(4):673-8. doi: 10.1093/oxfordjournals.jbchem.a130954.
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Structural studies of glycoasparagines from urine of a patient with aspartylglycosylaminuria (AGU).天冬氨酰葡糖胺尿症(AGU)患者尿液中糖天冬酰胺的结构研究。
FEBS Lett. 1977 Jun 15;78(2):284-6. doi: 10.1016/0014-5793(77)80324-4.
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Structural determination of three glycoasparagines isolated from the urine of a patient with aspartylglycosaminuria.从一名天冬氨酰葡糖胺尿症患者尿液中分离出的三种糖天冬酰胺的结构测定
Eur J Biochem. 1976 Aug 1;67(1):209-14. doi: 10.1111/j.1432-1033.1976.tb10651.x.
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Urinary abnormalities in fucosidosis. Characterization of a disaccharide and two glycoasparagines.岩藻糖苷贮积症中的泌尿异常。一种二糖和两种糖天冬酰胺的特征。
Eur J Biochem. 1978 Feb;83(2):513-21. doi: 10.1111/j.1432-1033.1978.tb12118.x.
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The glycoasparagines in urine of a patient with aspartylglycosaminuria.天冬氨酰葡糖胺尿症患者尿液中的糖天冬酰胺。
Biochem J. 1974 Jul;141(1):141-6. doi: 10.1042/bj1410141.
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Characterization of a mannose-containing glycoasparagine isolated from urine of a patient with aspartylglycosylaminuria (AGU).从一名天冬氨酰葡糖胺尿症(AGU)患者尿液中分离出的含甘露糖糖天冬酰胺的特性分析。
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Massive accumulation of Man2GlcNAc2-Asn in nonneuronal tissues of glycosylasparaginase-deficient mice and its removal by enzyme replacement therapy.在缺乏氨基己糖苷酶的小鼠非神经组织中,Man2GlcNAc2-Asn大量积累,以及通过酶替代疗法将其清除。
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Quantitative determination of 4-N-2-acetamido-2-deoxy-beta-D-glucopyranosyl-L-asparagine in the urine of patients with aspartylglycosaminuria by gas-liquid chromatography.用气液色谱法对天冬氨酰葡糖胺尿症患者尿液中的4-N-2-乙酰氨基-2-脱氧-β-D-吡喃葡糖基-L-天冬酰胺进行定量测定。
J Lab Clin Med. 1979 May;93(5):718-23.

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Characterization of four monosialo and a novel disialo Asn N-glycosides from the urine of a patient with aspartylglycosaminuria.来自一名天冬氨酰氨基葡糖苷尿症患者尿液中的四种单唾液酸和一种新型双唾液酸天冬酰胺 N-糖链的表征。
Glycoconj J. 1995 Jun;12(3):290-7. doi: 10.1007/BF00731332.
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Urinary oligosaccharide excretion in disorders of glycolipid, glycoprotein and glycogen metabolism. A review of screening for differential diagnosis.
糖脂、糖蛋白和糖原代谢紊乱时的尿低聚糖排泄。鉴别诊断筛查综述。
Eur J Pediatr. 1980 Sep;134(3):183-94. doi: 10.1007/BF00441471.