从天冬氨酰葡糖胺尿症（AGU）患者尿液中分离出的两种糖天冬酰胺的结构
Structure of two glycoasparagines isolated from the urine of patients with aspartylglycosylaminuria (AGU).
作者信息
Sugahara K, Akasaki M, Funakoshi I, Aula P, Yamashina I
出版信息
J Biochem. 1977 Nov;82(5):1499-501. doi: 10.1093/oxfordjournals.jbchem.a131841.
Abstract
The structures of two glycoasparagines composed of one mole each of N-acetylneuraminic acid, galactose, N-acetylglucosamine, and asparagine were determined by periodate oxidation, enzymatic degradation, and methylation analysis. The structures were NANAalpha2 leads to 3Galbeta1 leads to 4GlcNAcbeta leads to Asn and NANAalpha2 leads to 6Galbeta1 leads to 4GlcNAcbeta leads to Asn, respectively.
摘要
通过高碘酸盐氧化、酶促降解和甲基化分析确定了两种糖天冬酰胺的结构，每种糖天冬酰胺由一摩尔的N-乙酰神经氨酸、半乳糖、N-乙酰葡糖胺和天冬酰胺组成。其结构分别为NANAα2→3Galβ1→4GlcNAcβ→Asn和NANAα2→6Galβ1→4GlcNAcβ→Asn。
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