详细代谢途径研究对两例总儿茶酚胺输出量轻度增加的嗜铬细胞瘤的诊断价值
Diagnostic value of detailed metabolic pathway investigations in two cases of phaeochromocytoma with minimal increase in total catecholamine output.
作者信息
Brown J J, Ruthven C R, Sandler M
出版信息
J Clin Pathol. 1966 Sep;19(5):482-6. doi: 10.1136/jcp.19.5.482.
Abstract
Two patients with phaeochromocytoma having atypical biochemical features are described. Total catecholamine excretion was normal in one and only slightly raised in the other; both had a diagnostic rise in output of metadrenaline and 4-hydroxy-3-methoxymandelic acid whilst 4-hydroxy-3-methoxyphenylglycol excretion was increased in one of them. During hypertensive attacks adrenaline excretion became greater than that of noradrenaline. The diagnostic usefulness of separate adrenaline and noradrenaline estimations in addition to catecholamine metabolite assay is discussed. A lack of relationship between tumour catecholamine content and urinary catecholamine output is emphasized.
摘要
本文描述了两名具有非典型生化特征的嗜铬细胞瘤患者。其中一名患者的总儿茶酚胺排泄量正常，另一名仅略有升高；两人的间肾上腺素和4-羟基-3-甲氧基扁桃酸排出量均有诊断性升高，而其中一人的4-羟基-3-甲氧基苯乙二醇排泄量增加。在高血压发作期间，肾上腺素的排泄量超过去甲肾上腺素。文中讨论了除儿茶酚胺代谢物检测外，单独测定肾上腺素和去甲肾上腺素的诊断价值。强调了肿瘤儿茶酚胺含量与尿儿茶酚胺排出量之间缺乏相关性。
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Diagnostic value of detailed metabolic pathway investigations in two cases of phaeochromocytoma with minimal increase in total catecholamine output.详细代谢途径研究对两例总儿茶酚胺输出量轻度增加的嗜铬细胞瘤的诊断价值
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Ann Surg. 1969 Mar;169(3):376-85. doi: 10.1097/00000658-196903000-00012.
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Catecholamine-secreting tumours.分泌儿茶酚胺的肿瘤。
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本文引用的文献
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The quantitative separation of adrenaline and noradrenaline in biological fluids and tissue extracts.生物体液和组织提取物中肾上腺素和去甲肾上腺素的定量分离。
Br J Pharmacol Chemother. 1951 Mar;6(1):8-19. doi: 10.1111/j.1476-5381.1951.tb00614.x.
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Adrenal medullary function.肾上腺髓质功能。
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Diagnostic value of increased urinary output of pheochromocytoma.嗜铬细胞瘤尿量增加的诊断价值。
Lancet. 1950 Sep 23;2(6630):387. doi: 10.1016/s0140-6736(50)91342-0.
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Determination of 3-methoxy-4-hydroxymandelic acid in urine.尿液中3-甲氧基-4-羟基扁桃酸的测定
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Six cases of phaeochromocytoma with unusual clinical manifestations.6例具有不寻常临床表现的嗜铬细胞瘤
Br Med J. 1962 May 19;1(5289):1373-8. doi: 10.1136/bmj.1.5289.1373.
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Quantitative colorimetric method for estimation of 3-methoxy-4-hydroxymandelic acid in urine; value in diagnosis of phaeochromocytoma.尿液中3-甲氧基-4-羟基扁桃酸定量比色测定法；在嗜铬细胞瘤诊断中的价值
Lancet. 1959 Aug 15;2(7094):114-5. doi: 10.1016/s0140-6736(59)92220-2.
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A simple analysis for normetanephrine and metanephrine in urine.尿液中去甲变肾上腺素和变肾上腺素的简易分析。
Clin Chim Acta. 1960 May;5:406-14. doi: 10.1016/0009-8981(60)90146-7.
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A new method of large-scale preparation of hypertensin, with a note on its assay.一种大规模制备高血压素的新方法及关于其测定的说明。
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J Clin Pathol. 1965 May;18(3):288-92. doi: 10.1136/jcp.18.3.288.
10
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J Med Lab Technol. 1964 Oct;21:306-9.
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