Woods A E, Papadimitriou J M
J Pathol. 1977 Nov;123(3):165-74. doi: 10.1002/path.1711230306.
The phlogistic response of the stroma supporting a transplantable rat fibrosarcoma and the ability of animals bearing a neoplasm to mount an inflammatory reaction to non-specific stimuli were investigated. In the unstimulated neoplasm the concentration of macrophages in the stroma was similar to that of normal connective tissue. The mononuclear exudate induced by cotton pellets or glass coverslips implanted in the neoplastic tissue, however, was reduced when compared with that in normal connective tissues at both 7 and 14 days after implantation of these foreign bodies. Since the emigration of radioactively labelled monocytes in both inflamed normal connective tissue and inflamed stromal tissue in the neoplasm proved to be similar, the assumption has been made that neoplastic cells inhibit the local accumulation of the newly emigrated monocytes. This macrophage dispersing effect only occurs in the neoplasm and there is no systemic action. The only systemic effect detected is an anti-inflammatory action which was significant only between the 1st and the 2nd wk after transplantation of the neoplasm into neonatal recipients.
研究了支持可移植大鼠纤维肉瘤的基质的炎症反应以及荷瘤动物对非特异性刺激产生炎症反应的能力。在未受刺激的肿瘤中，基质中巨噬细胞的浓度与正常结缔组织相似。然而，当在肿瘤组织中植入棉球或玻璃盖片诱导单核细胞渗出时，在植入这些异物后7天和14天，与正常结缔组织相比，渗出均减少。由于放射性标记的单核细胞在炎症状态下的正常结缔组织和肿瘤的炎症基质组织中的迁移情况相似，因此推测肿瘤细胞会抑制新迁移的单核细胞在局部的聚集。这种巨噬细胞分散效应仅发生在肿瘤中，并无全身作用。检测到的唯一全身效应是抗炎作用，仅在将肿瘤移植到新生受体后第1周和第2周之间具有显著性。
