King E G, Wood D E, Morley T P
Can Med Assoc J. 1966 Aug 27;95(9):381-9.
Intra-arterially injected macroaggregates of radioiodinated human serum albumin were used in the detection of brain tumours in mice and in human subjects. The mean size of particle used was 29 mu. Brain-to-tumour ratios in ependymoblastoma-bearing mice ranged from 43.5:1 to 2.8:1. Autoradiographs of brain and tumour from sacrificed mice indicated that most of the macroaggregates were trapped within cerebral and cerebellar grey matter. Tumour retained little activity. Particles within small vessels did not cause complete obstruction, although temporary vessel spasm, cessation and reversal of flow were observed. Twelve patients with clinically evident brain tumours received carotid or vertebral injections of macroaggregates. Ten had histologically proved tumours, and six of these were correctly localized by external scanning. The quality of the scans was not superior to that obtained with other tracers currently in use. Because four patients developed transient neurological complications that could be attributed to the procedure, the clinical pilot study was terminated.
动脉内注射放射性碘化人血清白蛋白大颗粒用于检测小鼠和人类受试者的脑肿瘤。所用颗粒的平均大小为29微米。携带室管膜母细胞瘤的小鼠脑与肿瘤的比值范围为43.5:1至2.8:1。处死小鼠的脑和肿瘤的放射自显影片显示，大多数大颗粒被困在大脑和小脑灰质内。肿瘤保留的活性很少。小血管内的颗粒并未导致完全阻塞，尽管观察到了暂时的血管痉挛、血流停止和逆流。12例临床上有明显脑肿瘤的患者接受了颈动脉或椎动脉注射大颗粒。10例经组织学证实患有肿瘤，其中6例通过外部扫描正确定位。扫描质量并不优于目前使用的其他示踪剂所获得的质量。由于4例患者出现了可归因于该操作的短暂神经并发症，临床试点研究终止。
