Talamantes F, Jang H
J Toxicol Environ Health. 1977 Nov;3(4):713-20. doi: 10.1080/15287397709529606.
In consideration of the influence that chlorinated hydrocarbon insecticides may exert on mammalian physiology, the present study was performed to investigate the effects of neonatal chlordane administration on body growth and endocrine development in female mice. Mice receiving 0.075 or 0.15 mg of alpha or gamma chlordane on day 2, 3, and 4 of life were observed to have growth rates depressed to varying extents depending on the concentration or the type of isomer that was utilized. Eye and vaginal opening in the neonatally treated mice were observed to be delayed to varying degrees, which were dependent on which isomer was used. The total effects observed in the neonatally treated mice were not found to reflect a dose-related response.
考虑到氯代烃杀虫剂可能对哺乳动物生理产生的影响，本研究旨在调查新生小鼠给予氯丹对其身体生长和内分泌发育的影响。在出生后第2、3和4天接受0.075或0.15毫克α或γ氯丹的小鼠，观察到其生长速率根据所使用异构体的浓度或类型而不同程度地降低。新生处理小鼠的眼睛睁开和阴道开口被观察到不同程度地延迟，这取决于所使用的异构体。在新生处理小鼠中观察到的总体影响未发现反映剂量相关反应。
