Washida H, Ueda K, Watanabe H
Jpn J Antibiot. 1977 Oct;30(10):802-5.
S-6436 (a preparation consisting of 30% of non-enteric coated granules and 70% of enteric coated ones) was orally administered to the patients with acute pyelonephritis, and the following results were obtained: 1. Subjective symptoms: Very good in 13 cases (65%), good in 1, fair in 2 and poor in 4. 2. Urine finding: Very good in 13 cases (65%), good in 3 and poor in 4. 3. Disappearance of causative organisms: Organisms which were identified in the first examination were 17 strains of E. coli, one each of Pr. vulgalis, Klebsiella and Staph. epidermidis, 3 of Strept. faecalis, and 3 of mixed infections. Very good effect was observed in 16 cases, good in 1, fair in 1 and poor in 2. 4. Total evaluation: Very good in 13 cases (65%), good in 4 (20%) and poor in 3 (15%). 5. Slight discomfort in abdomen was observed in only one patient, but disappeared by administration of digestive. 6. S-6436 was given to the patients with acute pyelonephritis twice a day expecting that the drug has satisfactory clinical efficacy.
将S - 6436（一种由30%的非肠溶包衣颗粒和70%的肠溶包衣颗粒组成的制剂）口服给予急性肾盂肾炎患者，得到以下结果：1. 主观症状：13例（65%）非常好，1例良好，2例一般，4例较差。2. 尿液检查结果：13例（65%）非常好，3例良好，4例较差。3. 致病微生物消失情况：首次检查中鉴定出的微生物有17株大肠杆菌、1株普通变形杆菌、1株克雷伯菌和1株表皮葡萄球菌、3株粪肠球菌以及3例混合感染。16例效果非常好，1例良好，1例一般，2例较差。4. 总体评价：13例（65%）非常好，4例（20%）良好，3例（15%）较差。5. 仅1例患者出现轻微腹部不适，但服用助消化药物后消失。6. 考虑到该药物具有满意的临床疗效，将S - 6436给予急性肾盂肾炎患者，每日两次。
