头孢氨苄缓释剂（S-6436）与泌尿生殖道感染（作者译）

[Sustained release cephalexin (S-6436) and genitourinary tract infection (author's transl)].

Furusawa T, Tanaka S

Jpn J Antibiot. 1977 Oct;30(10):806-18.

Abstract

Forty (40) patients with comparatively simply urinary tract infections were orally administered 1 g/day of sustained release cephalexin (S-6436) in two divided doses (after breakfast and dinner) for 7 approximately 14 days, and 20 patients complicated with chronic urinary tract infections or epididymitis were orally given 2 g/day of the drug in two divided doses (after breakfast and dinner) for 7 approximately 28 days. Thirty six (90%) patients of the 40 receiving 1 g/day and seventeen (85%) of the 20 with 2 g/day satisfactorily responded to the drug. 2) Disappearance of organisms was observed in 43 patients (75.4%) of the 57 with urinary tract infections on whom bacteriological examination was conducted. Three (7.0%) of the 43, however, recurred within 7 days after the treatment. In six patients (10.5%) of the 57, the organisms were replaced. 3) Side effects such as gastrointestinal disturbance, allergic reactions, abnormality of blood picture, and impairments of renal and hepatic functions were examined and no such side effects were found except uriticaria in whole body was observed in only one patient with 1 g/day, which disappeared after discontinuation of the administration of the drug.

摘要

40例患有相对单纯性尿路感染的患者，口服缓释头孢氨苄（S - 6436），剂量为每日1克，分两次（早餐后和晚餐后）服用，疗程约7至14天；20例合并慢性尿路感染或附睾炎的患者，口服该药物，剂量为每日2克，分两次（早餐后和晚餐后）服用，疗程约7至28天。接受每日1克剂量的40例患者中有36例（90%）对药物反应良好，接受每日2克剂量的20例患者中有17例（85%）对药物反应良好。2) 在进行了细菌学检查的57例尿路感染患者中，43例（75.4%）的细菌消失。然而，这43例中有3例（7.0%）在治疗后7天内复发。57例中有6例（10.5%）的细菌被其他细菌取代。3) 对胃肠道不适、过敏反应、血常规异常以及肾和肝功能损害等副作用进行了检查，除了1例每日服用1克剂量的患者出现全身荨麻疹外，未发现此类副作用，停药后荨麻疹消失。