• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

无菌小鼠的支原体肺炎。I. 肺炎支原体、唾液支原体和肺支原体对普通和无菌小鼠肺部的致病性。

Pneumonia due to mycoplasma in gnotobiotic mice. I. Pathogenicity of Mycoplasma pneumoniae, Mycoplasma salivarium, and Mycoplasma pulmonis for the lungs of conventional and gnotobiotic mice.

作者信息

Lutsky I I, Organick A B

出版信息

J Bacteriol. 1966 Oct;92(4):1154-63. doi: 10.1128/jb.92.4.1154-1163.1966.

DOI:10.1128/jb.92.4.1154-1163.1966
PMID:5926744
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC276391/
Abstract

Lutsky, Irving I. (Marquette University School of Medicine, Milwaukee, Wis.), and Avrum B. Organick. Pneumonia due to mycoplasma in gnotobiotic mice. I. Pathogenicity of Mycoplasma pneumoniae, Mycoplasma salivarium, and Mycoplasma pulmonis for the lungs of conventional and gnotobiotic mice. J. Bacteriol. 92:1154-1163. 1966.-Two species of mycoplasma of human origin, Mycoplasma pneumoniae and M. salivarium, were tested for their ability to produce respiratory disease in the Ha/ICR mouse when inoculated by the intranasal route. The mouse pathogen M. pulmonis was studied as a positive control. Conventional and gnotobiotic Ha/ICR mice were employed, the latter to provide a system free from indigenous mycoplasma and bacteria. Pneumonia from which mycoplasma were isolated was produced in all groups of the conventional Ha/ICR mice, including those inoculated with sterile broth. Only M. pulmonis produced disease when inoculated intranasally into the gnotobiotic mice, and the gross and microscopic lesions resembled those described in conventional mice. The gnotobiotic mouse provided a tool to study the pathogenicity of different mycoplasma species, and indicated marked differences in host specificity that could not be clearly seen when conventional mice were used.

摘要

卢茨基，欧文·I.（威斯康星州密尔沃基市马凯特大学医学院），以及阿夫鲁姆·B. 奥加尼克。无菌动物小鼠中的支原体肺炎。I. 肺炎支原体、唾液支原体和肺支原体对常规和无菌动物小鼠肺部的致病性。《细菌学杂志》92:1154 - 1163。1966年。- 通过鼻内接种，测试了两种源自人类的支原体，即肺炎支原体和唾液支原体，在Ha/ICR小鼠中引发呼吸道疾病的能力。将小鼠病原体肺支原体作为阳性对照进行研究。使用了常规和无菌的Ha/ICR小鼠，后者用于提供一个无原生支原体和细菌的系统。在所有常规Ha/ICR小鼠组中都产生了分离出支原体的肺炎，包括接种无菌肉汤的那些组。仅将肺支原体经鼻内接种到无菌动物小鼠中时会引发疾病，其大体和微观病变与常规小鼠中描述的相似。无菌动物小鼠为研究不同支原体物种的致病性提供了一种工具，并表明在宿主特异性方面存在明显差异，而使用常规小鼠时无法清晰看出这些差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d30/276391/5e51b4e7b71d/jbacter00416-0395-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d30/276391/ca2089b65f13/jbacter00416-0391-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d30/276391/82dddd56d8f4/jbacter00416-0393-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d30/276391/c6045c038c8d/jbacter00416-0393-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d30/276391/40c873fc5bdb/jbacter00416-0394-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d30/276391/11308c249ec3/jbacter00416-0394-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d30/276391/5e51b4e7b71d/jbacter00416-0395-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d30/276391/ca2089b65f13/jbacter00416-0391-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d30/276391/82dddd56d8f4/jbacter00416-0393-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d30/276391/c6045c038c8d/jbacter00416-0393-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d30/276391/40c873fc5bdb/jbacter00416-0394-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d30/276391/11308c249ec3/jbacter00416-0394-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d30/276391/5e51b4e7b71d/jbacter00416-0395-a.jpg

相似文献

1
Pneumonia due to mycoplasma in gnotobiotic mice. I. Pathogenicity of Mycoplasma pneumoniae, Mycoplasma salivarium, and Mycoplasma pulmonis for the lungs of conventional and gnotobiotic mice.无菌小鼠的支原体肺炎。I. 肺炎支原体、唾液支原体和肺支原体对普通和无菌小鼠肺部的致病性。
J Bacteriol. 1966 Oct;92(4):1154-63. doi: 10.1128/jb.92.4.1154-1163.1966.
2
Pneumonia due to mycoplasma in gnotobiotic mice. II. Localization of Mycoplasma pulmonis in the lungs of infected gnotobiotic mice by electron microscopy.悉生小鼠支原体肺炎。II. 用电子显微镜观察肺炎支原体在感染悉生小鼠肺内的定位
J Bacteriol. 1966 Oct;92(4):1164-76. doi: 10.1128/jb.92.4.1164-1176.1966.
3
Pneumonia due to Mycoplasma in gnotobiotic mice. 3. Lesions in the lungs of gnotobiotic mice after multiple intranasal inoculations of broth cultures of Mycoplasma pneumoniae.悉生小鼠中的支原体肺炎。3. 多次经鼻接种肺炎支原体肉汤培养物后悉生小鼠肺部的病变
J Bacteriol. 1968 Jun;95(6):2310-6. doi: 10.1128/jb.95.6.2310-2316.1968.
4
Mycoplasma pulmonis infection in gnotobiotic and conventional mice: aspects of pathogenicity including microbial enumeration and studies of tracheal involvement.
Lab Anim Sci. 1976 Jun;26(3):419-29.
5
Pathogenicity of some Mycoplasma and Acholeplasma species in the lungs of gnotobiotic calves.某些支原体和无胆甾原体属菌种在无菌犊牛肺部的致病性
Res Vet Sci. 1979 Sep;27(2):233-7.
6
Role of Pasteurella pneumotropica and Mycoplasma pulmonis in murine pneumonia.嗜肺巴斯德氏菌和肺支原体在小鼠肺炎中的作用。
J Bacteriol. 1969 Jan;97(1):337-49. doi: 10.1128/jb.97.1.337-349.1969.
7
Reproducible pneumonia in gnotobiotic piglets induced with broth cultures of Mycoplasma hyopneumoniae and the effect of animal passage on virulence.用猪肺炎支原体肉汤培养物诱导无菌仔猪发生可重复性肺炎以及动物传代对毒力的影响。
Res Vet Sci. 1984 Mar;36(2):153-63.
8
Immunological analysis and pathological examination of gnotobiotic mice monoassociated with Mycoplasma pneumoniae.与肺炎支原体单联的悉生小鼠的免疫学分析及病理学检查
J Med Microbiol. 2009 Jun;58(Pt 6):697-705. doi: 10.1099/jmm.0.007872-0.
9
Experimental Mycoplasma pulmonis infection in pathogen-free mice. Models for studying mycoplasmosis of the respiratory tract.无特定病原体小鼠的实验性肺支原体感染。研究呼吸道支原体病的模型。
Am J Pathol. 1973 Jul;72(1):63-90.
10
Pneumonia due to Mycoplasma in gnotobiotic mice. IV. Localization and identification of Mycoplasma pulmonis in the bronchi of infected gnotobiotic mice by immunofluorescence and by light microscopy.无菌小鼠支原体肺炎。IV. 通过免疫荧光和光学显微镜对感染无菌小鼠支气管中的肺支原体进行定位和鉴定。
J Bacteriol. 1968 Jul;96(1):250-8. doi: 10.1128/jb.96.1.250-258.1968.

引用本文的文献

1
Intranasal inoculation of Mycoplasma pulmonis in mice with severe combined immunodeficiency (SCID) causes a wasting disease with grave arthritis.用严重联合免疫缺陷（SCID）小鼠进行肺炎支原体鼻内接种会引发一种伴有严重关节炎的消耗性疾病。
Clin Exp Immunol. 1994 Dec;98(3):388-94. doi: 10.1111/j.1365-2249.1994.tb05502.x.
2
Immunobiology of germfree mice infected with Nocardia asteroides.感染星状诺卡菌的无菌小鼠的免疫生物学
Infect Immun. 1980 Aug;29(2):733-43. doi: 10.1128/iai.29.2.733-743.1980.
3
Delayed hypersensitivity to nonviable Mycoplasma pulmonis in mice is enhanced by dextran sulfate.

本文引用的文献

1
EXPERIMENTAL INFECTION WITH MYCOPLASMA PNEUMONIAE (EATON'S AGENT).肺炎支原体（伊顿氏因子）的实验性感染
J Exp Med. 1965 Jun 1;121(6):1071-86. doi: 10.1084/jem.121.6.1071.
2
BIOCHEMICAL, MORPHOLOGICAL, AND SEROLOGICAL CHARACTERIZATION OF MYCOPLASMA OF MURINE ORIGIN.鼠源支原体的生化、形态学及血清学特性
J Infect Dis. 1965 Apr;115:171-85. doi: 10.1093/infdis/115.2.171.
3
ESTABLISHMENT OF HUMAN INDIGENOUS BACTERIA IN GERM-FREE MICE.无菌小鼠中人类本土细菌的定植
硫酸葡聚糖可增强小鼠对非存活肺支原体的迟发型超敏反应。
Infect Immun. 1983 Feb;39(2):823-9. doi: 10.1128/iai.39.2.823-829.1983.
4
Pneumonia due to mycoplasma in gnotobiotic mice. II. Localization of Mycoplasma pulmonis in the lungs of infected gnotobiotic mice by electron microscopy.悉生小鼠支原体肺炎。II. 用电子显微镜观察肺炎支原体在感染悉生小鼠肺内的定位
J Bacteriol. 1966 Oct;92(4):1164-76. doi: 10.1128/jb.92.4.1164-1176.1966.
5
Pneumonia due to Mycoplasma in gnotobiotic mice. 3. Lesions in the lungs of gnotobiotic mice after multiple intranasal inoculations of broth cultures of Mycoplasma pneumoniae.悉生小鼠中的支原体肺炎。3. 多次经鼻接种肺炎支原体肉汤培养物后悉生小鼠肺部的病变
J Bacteriol. 1968 Jun;95(6):2310-6. doi: 10.1128/jb.95.6.2310-2316.1968.
6
[Spontaneous autoimmune disease of the rat].
Klin Wochenschr. 1970 Aug 1;48(15):951-3. doi: 10.1007/BF01487641.
7
The gnotobiotic animal as a tool in the study of host microbial relationships.无菌动物作为研究宿主与微生物关系的工具。
Bacteriol Rev. 1971 Dec;35(4):390-429. doi: 10.1128/br.35.4.390-429.1971.
8
The interaction in vitro of Mycoplasma pulmonis with mouse peritoneal macrophages and L-cells.肺炎支原体与小鼠腹腔巨噬细胞和L细胞的体外相互作用。
J Exp Med. 1971 Feb 1;133(2):231-59. doi: 10.1084/jem.133.2.231.
9
Murine chronic respiratory disease. Significance as a research complication and experimental production with Mycoplasma pulmonis.小鼠慢性呼吸道疾病。作为一种研究并发症的意义以及用肺支原体进行实验性诱发
Am J Pathol. 1971 Sep;64(3):675-708.
10
Role of Pasteurella pneumotropica and Mycoplasma pulmonis in murine pneumonia.嗜肺巴斯德氏菌和肺支原体在小鼠肺炎中的作用。
J Bacteriol. 1969 Jan;97(1):337-49. doi: 10.1128/jb.97.1.337-349.1969.
J Bacteriol. 1964 Nov;88(5):1316-23. doi: 10.1128/jb.88.5.1316-1323.1964.
4
A study of the properties of Eaton's primary atypical pneumonia organism.伊顿原发性非典型肺炎病原体特性的研究。
J Gen Microbiol. 1962 Oct;29:271-90. doi: 10.1099/00221287-29-2-271.
5
Growth on artificial medium of an agent associated with atypical pneumonia and its identification as a PPLO.一种与非典型肺炎相关的病原体在人工培养基上的生长及其被鉴定为类胸膜肺炎微生物。
Proc Natl Acad Sci U S A. 1962 Jan 15;48(1):41-9. doi: 10.1073/pnas.48.1.41.
6
Infection in laboratory animals with pleuropneumonia-like organisms.
J Natl Cancer Inst. 1958 May;20(5):911-9.