Morrow D T, Robinette L R, Saubert C W, Van Hoosier G L
Lab Anim Sci. 1977 Oct;27(5 Pt 1):679-81.
Experiments using the rat to study the effect of forced exercise on various physiologic and biochemical processes were complicated by the occurrence of poditis. Staphylococcus aureus was isolated from two affected rats and a tentative diagnosis of staphylococcal pododermatitis was made. In a subsequent study, poditis again occurred and S aureus was isolated from the rats, cages, exercise wheels, and attendants. Subcutaneous inoculation of six rats with the organism failed to reproduce the disease. The isolation of S aureus, and the apparent response to hygienic and therapeutic procedures and a change in exercise apparatus, suggested a traumatic and infectious etiology. However, the respective roles of trauma and S aureus or other microorganisms were not resolved.
利用大鼠研究强迫运动对各种生理和生化过程影响的实验因足皮炎的发生而变得复杂。从两只患病大鼠中分离出金黄色葡萄球菌，并初步诊断为葡萄球菌性足皮炎。在随后的一项研究中，足皮炎再次出现，并且从大鼠、笼子、运动轮和饲养员身上分离出了金黄色葡萄球菌。对六只大鼠进行该病菌的皮下接种未能使疾病重现。金黄色葡萄球菌的分离，以及对卫生和治疗程序的明显反应以及运动器械的改变，提示了创伤性和感染性病因。然而，创伤与金黄色葡萄球菌或其他微生物各自的作用尚未明确。
