Forsyth B R, Coates H V, Chanock R M
J Bacteriol. 1966 Mar;91(3):1270-6. doi: 10.1128/jb.91.3.1270-1276.1966.
Forsyth, Ben R. (National Institute of Allergy and Infectious Diseases, Bethesda, Md.), Helen V. Coates, and Robert M. Chanock. Biophysical studies of respiratory syncytial virus. II. Identification of two soluble complement-fixing antigens of respiratory syncytial virus. J. Bacteriol. 91:1270-1276. 1966.-Column chromatography of concentrated preparations was used to separate two antigenic components from the "soluble complement-fixing (CF) antigen" of respiratory syncytial (RS) virus. These antigens, designated antigen A and antigen B, stimulated homologous but not heterologous CF antibodies. Only antigen A stimulated the production of neutralizing antibody in guinea pigs. There was a dissociation between the CF and neutralizing antibody responses of guinea pigs immunized with antigen A. The two antigens were shown to have different molecular size, density, and sensitivity to lipolytic agents. Both antigens appeared to be components of the RS viral particle. Serological studies demonstrated that both antigens were formed during RS virus infection of children and adults.
福赛思，本·R.（国立过敏与传染病研究所，马里兰州贝塞斯达），海伦·V. 科茨，以及罗伯特·M. 查诺克。呼吸道合胞病毒的生物物理学研究。II. 呼吸道合胞病毒两种可溶性补体结合抗原的鉴定。《细菌学杂志》91:1270 - 1276。1966年。——采用浓缩制剂的柱色谱法从呼吸道合胞（RS）病毒的“可溶性补体结合（CF）抗原”中分离出两种抗原成分。这些抗原，分别命名为抗原A和抗原B，能刺激同源而非异源的CF抗体。只有抗原A能刺激豚鼠产生中和抗体。用抗原A免疫的豚鼠，其CF抗体反应和中和抗体反应之间出现了分离。已表明这两种抗原具有不同的分子大小、密度以及对脂解剂的敏感性。两种抗原似乎都是RS病毒颗粒的成分。血清学研究表明，两种抗原都是在儿童和成人感染RS病毒期间形成的。
