纤维蛋白原与纤维蛋白的稳定复合物。

Stable complex of fibrinogen and fibrin.

作者信息

Sasaki T, Page I H, Shainoff J R

出版信息

Science. 1966 May 20;152(3725):1069-71. doi: 10.1126/science.152.3725.1069.

DOI:10.1126/science.152.3725.1069

Abstract

Fibrin-stabilizing factor acts on monomeric fibrin combined with fibrinogen to form a stable complex that is soluble at physiologic pH and ionic strength. The complex has been isolated by chromatography on agarose gel and characterized by sedimentation rate near 24 S(w.20) at both pH 5.3 and 7.4, by coagulability when treated with thrombin, and by content of fibrinopeptides. Formation of the complex could provide a pathway for solubilization of monomeric fibrin produced in circulating blood.

摘要

纤维蛋白稳定因子作用于与纤维蛋白原结合的单体纤维蛋白，形成一种在生理pH值和离子强度下可溶的稳定复合物。该复合物已通过琼脂糖凝胶色谱法分离，并通过在pH 5.3和7.4时接近24 S（w.20）的沉降速率、用凝血酶处理时的凝固性以及纤维蛋白肽含量进行了表征。该复合物的形成可能为循环血液中产生的单体纤维蛋白的溶解提供一条途径。