Engelhardt W, Penning W, Nagy M
Med Klin. 1977 Dec 2;72(48):2077-80.
Glucose tolerance test (oral standard glucose tolerance test) was carried out--before starting radiotherapy--in 99 female patients suffering from inoperable cancer of the genitals. 47 of these patients were administered gestonoroncapronate (600 mg/week) during radiotherapy. Glucose tolerance was tested anew after the last irradiation. During the first hour after the second glucose tolerance test, an improvement of glucose tolerance was stated in the patients' group treated with gestonoroncapronate, whereas during the second hour a deterioration of glucose tolerance was found. The patients' collective treated without gestonoroncapronate demonstrated an improved glucose tolerance during the entire second course of the test. A decrease of capacity of the islet cell organ, induced by gestonoroncapronate, is discussed.
在99例患有无法手术的生殖器癌的女性患者中，于放疗开始前进行了葡萄糖耐量试验（口服标准葡萄糖耐量试验）。其中47例患者在放疗期间接受了孕三烯酮（600毫克/周）治疗。在最后一次照射后再次进行葡萄糖耐量测试。在第二次葡萄糖耐量试验后的第一小时，接受孕三烯酮治疗的患者组的葡萄糖耐量有所改善，而在第二小时则发现葡萄糖耐量恶化。未接受孕三烯酮治疗的患者群体在整个第二次测试过程中葡萄糖耐量有所改善。文中讨论了孕三烯酮诱导的胰岛细胞器官功能下降。
