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[意大利北部乙型急性病毒性肝炎样本中乙肝表面抗原亚型的分布]

[Distribution of HB s Ag subtypes in a sample of acute viral hepatitis of type B in Northern Italy].

作者信息

Gerna G, Fiori G P, Cattaneo E, Achilli G, Cereda P

出版信息

Minerva Med. 1976 May 9;67(23):1494-9.

PMID:59324
Abstract

82 HBsAg from acute hepatitis B patients living in Northern Italy were subtyped. HBsAg has been detected by immunodiffusion (ID), electrosyneresis (ES), complement fixation (CF) and radioimmunoassay (RIA, Kit Ausria I and II, Abbott). Subtyping was performed by ES in 50 and by ID in 30 of the 82 assayed sera. An higher frequency of ayw subtype (83,1%) in comparison with adw subtype (16,9%) has been observed. No difference was found between adw and ayw subtypes analyzed as far as geographic-ethnic characters, incubation time, course and prognosis of the disease or the biohumoral indices. No patient was found to have both y and d specificities and so r determinant was never found.

摘要

对居住在意大利北部的急性乙型肝炎患者的82份乙肝表面抗原(HBsAg)进行了亚型分析。采用免疫扩散法(ID)、电渗析法(ES)、补体结合法(CF)和放射免疫分析法(RIA,Ausria I和II试剂盒,雅培公司)检测HBsAg。在82份检测血清中,50份通过ES进行亚型分析,30份通过ID进行亚型分析。观察到ayw亚型的频率(83.1%)高于adw亚型(16.9%)。就地理种族特征、潜伏期、病程、疾病预后或生物体液指标而言,分析的adw和ayw亚型之间未发现差异。未发现患者同时具有y和d特异性,因此从未发现r决定簇。

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