分离的大鼠肝细胞中鬼笔环肽反应的温度依赖性
Temperature dependence of phalloidin response in isolated rat hepatocytes.
作者信息
Frimmer M, Rufeger U
出版信息
Naunyn Schmiedebergs Arch Pharmacol. 1977 Nov;300(2):193-4. doi: 10.1007/BF00505051.
PMID:593442
Abstract
Below 21 degrees C isolated hepatocytes are insensitive to phalloidin. Between 21 and 30 degrees C the amount of affected cells increases to nearly maximal values, whereas a further rise of the temperature has little additional effect. These findings suggest that phase transition of membranal lipids might be responsible for the unusual temperature characteristics. The fluidity of lipids seems to control an early step of the phalloidin response.
摘要
在21摄氏度以下，分离的肝细胞对鬼笔环肽不敏感。在21至30摄氏度之间，受影响细胞的数量增加到几乎最大值，而温度进一步升高则几乎没有额外影响。这些发现表明膜脂的相变可能是这种异常温度特性的原因。脂质的流动性似乎控制着鬼笔环肽反应的早期步骤。
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