[鬼笔环肽拮抗剂。2. 二氢杨梅素对离体肝细胞鬼笔环肽中毒的保护作用]
[Phalloidin antagonists. 2. Protective effect of disilybine in phalloidin poisoning of isolated hepatocytes].
作者信息
Petzinger V E, Homann J, Frimmer M
出版信息
Arzneimittelforschung. 1975 Apr;25(4):571-6.
PMID:1098677
Abstract
Phalloidin produces marked protrusions on the surface of isolated hepatocytes prepared from rat livers. This typical in-vitro effect of the mushroom toxin is prevented or inhibited by preincubation with disilybin. The antagonistic effect depends on the concentration of disilybin and might be caused by an inhibition of phalloidin binding.
摘要
鬼笔环肽会在从大鼠肝脏分离出的肝细胞表面产生明显的突起。这种蘑菇毒素典型的体外效应可通过与水飞蓟宾预孵育来预防或抑制。这种拮抗作用取决于水飞蓟宾的浓度，可能是由鬼笔环肽结合的抑制所引起的。
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