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N-取代氨基乙醇的磷酸酯掺入脑和肝脏的磷脂中。

The incorporation of the phosphate esters of N-substituted aminoethanols into the phospholipids of brain and liver.

作者信息

Ansell G B, Chojnacki T

出版信息

Biochem J. 1966 Jan;98(1):303-10. doi: 10.1042/bj0980303.

DOI:10.1042/bj0980303
PMID:5938655
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1264831/
Abstract
  1. The phosphate esters of dimethylaminoethanol and monomethylaminoethanol can be incorporated from their cytidine diphosphate esters into the phospholipids of brain and liver dispersions; the deoxycytidine nucleotides of the same bases are less effective precursors. 2. The cytidylyltransferases of brain and liver are less effective in forming the cytidine diphosphate esters of monomethylaminoethanol and dimethylaminoethanol than those of ethanolamine and choline.
摘要
  1. 二甲基氨基乙醇和单甲基氨基乙醇的磷酸酯可从其胞苷二磷酸酯掺入脑和肝匀浆的磷脂中；相同碱基的脱氧胞苷核苷酸是效果较差的前体。2. 脑和肝的胞苷酰转移酶在形成单甲基氨基乙醇和二甲基氨基乙醇的胞苷二磷酸酯方面比乙醇胺和胆碱的胞苷酰转移酶效率更低。

相似文献

1
The incorporation of the phosphate esters of N-substituted aminoethanols into the phospholipids of brain and liver.N-取代氨基乙醇的磷酸酯掺入脑和肝脏的磷脂中。
Biochem J. 1966 Jan;98(1):303-10. doi: 10.1042/bj0980303.
2
The biosynthesis of cytidine diphosphate esters in rat liver and Neurospora crassa.大鼠肝脏和粗糙脉孢菌中胞苷二磷酸酯的生物合成。
Acta Biochim Pol. 1969;16(4):357-63.
3
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J Neurochem. 1965 Jul;12(7):649-56. doi: 10.1111/j.1471-4159.1965.tb04258.x.
4
ON THE IN VITRO FORMATION OF PHOSPHOLIPIDS CONTAINING UNNATURAL BASES, VIA THE CYTIDINE MECHANISM.通过胞苷机制在体外合成含非天然碱基的磷脂
Acta Biochim Pol. 1964;11:11-23.
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Studies on the origin of choline in the brain of the rat.大鼠脑中胆碱来源的研究。
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Endocrinology. 1969 Dec;85(6):1216-7. doi: 10.1210/endo-85-6-1216.
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The incorporation of 32P-labelled phosphoric esters of glycerol, choline, ethanolamine, and serine into phospholipids of guinea pigs tissues in vitro.体外将32P标记的甘油、胆碱、乙醇胺和丝氨酸的磷酸酯掺入豚鼠组织的磷脂中。
Acta Biochim Pol. 1961;8:111-22.
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The formation of phospholipids containing unnatural bases by the cytidine pathway.通过胞苷途径形成含非天然碱基的磷脂。
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9
Isotope dilution determinations and other studies of cytidine diphosphate choline, cytidine diphosphate ethanolamine, deoxycytidine diphosphate choline, and deoxycytidine diphosphate ethanolamine in liver and liver tumors.肝脏及肝肿瘤中胞苷二磷酸胆碱、胞苷二磷酸乙醇胺、脱氧胞苷二磷酸胆碱和脱氧胞苷二磷酸乙醇胺的同位素稀释测定及其他研究。
J Natl Cancer Inst. 1971 Feb;46(2):435-41.
10
Biosynthesis of phosphatides of N-ethyl analogs of choline in vivo and in vitro.胆碱N-乙基类似物磷脂在体内和体外的生物合成。
Arch Biochem Biophys. 1968 Mar 11;123(3):462-7. doi: 10.1016/0003-9861(68)90167-7.

引用本文的文献

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Historical perspective: phosphatidylserine and phosphatidylethanolamine from the 1800s to the present.历史视角：从 19 世纪至今的磷脂酰丝氨酸和磷脂酰乙醇胺。
J Lipid Res. 2018 Jun;59(6):923-944. doi: 10.1194/jlr.R084004. Epub 2018 Apr 16.
2
The metabolism of [Me-14C]choline in the brain of the rat in vivo.大鼠脑内[甲基-14C]胆碱的体内代谢
Biochem J. 1968 Nov;110(2):201-6. doi: 10.1042/bj1100201.
3
Regulation of phosphatidylcholine biosynthesis in Saccharomyces cerevisiae.酿酒酵母中磷脂酰胆碱生物合成的调控
J Bacteriol. 1971 Mar;105(3):837-43. doi: 10.1128/jb.105.3.837-843.1971.
4
The labeling of brain ethanolamine phosphoglycerides from cytidine diphosphate ethanolamine in vitro.体外由胞苷二磷酸乙醇胺标记脑乙醇胺磷酸甘油酯
Lipids. 1970 Sep;5(9):734-42. doi: 10.1007/BF02531385.
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The incorporation of phosphorylethanolamine into the phospholipids of brain microsomes in vitro.体外将磷酸乙醇胺掺入脑微粒体的磷脂中。
Lipids. 1970 Sep;5(9):725-33. doi: 10.1007/BF02531384.
6
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7
Quantitation of phosphatidyl N-methyl and N,N-dimethyl aminoethanol in liver and lung of N-methylaminoethanol fed rats.喂食N-甲基氨基乙醇的大鼠肝脏和肺中磷脂酰N-甲基和N,N-二甲基氨基乙醇的定量分析
Lipids. 1974 Feb;9(2):81-5. doi: 10.1007/BF02532130.
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The cytidine mechanism and methylation pathway in the formation of N-methylated ethanolamine phosphoglycerides in Neurospora crassa.粗糙脉孢菌中N-甲基乙醇胺磷酸甘油酯形成过程中的胞苷机制和甲基化途径。
Mol Cell Biochem. 1974 Apr 15;3(2):143-51. doi: 10.1007/BF01659186.
9
The incorporation of monomethylethanolamine and dimethylethanolamine in fetal brain aggregating cell culture.
Neurochem Res. 1988 Jan;13(1):1-8. doi: 10.1007/BF00971848.
10
Head-group specificity for feedback regulation of CTP:phosphocholine cytidylyltransferase.CTP：磷酸胆碱胞苷转移酶反馈调节的头部基团特异性
Biochem J. 1990 Sep 15;270(3):749-54. doi: 10.1042/bj2700749.

本文引用的文献

1
The biosynthesis of choline methyl groups by the rat.大鼠胆碱甲基基团的生物合成。
Biochem J. 1951 Jan;48(1):27-32.
2
A new method for synthesis of cytidine diphosphate-ethanolamine and cytidine diphosphatecholine.一种合成胞苷二磷酸乙醇胺和胞苷二磷酸胆碱的新方法。
Chem Pharm Bull (Tokyo). 1962 Mar;10:231-7. doi: 10.1248/cpb.10.231.
3
The incorporation of 32P-labelled phosphoric esters of glycerol, choline, ethanolamine, and serine into phospholipids of guinea pigs tissues in vitro.体外将32P标记的甘油、胆碱、乙醇胺和丝氨酸的磷酸酯掺入豚鼠组织的磷脂中。
Acta Biochim Pol. 1961;8:111-22.
4
ON THE IN VITRO FORMATION OF PHOSPHOLIPIDS CONTAINING UNNATURAL BASES, VIA THE CYTIDINE MECHANISM.通过胞苷机制在体外合成含非天然碱基的磷脂
Acta Biochim Pol. 1964;11:11-23.
5
PHOSPHORUS COMPOUNDS IN ANIMAL TISSUES. VII. ENZYMATIC FORMATION OF DEOXYCYTIDINE DIPHOSPHATE CHOLINE AND LECITHIN BY TISSUE HOMOGENATES.动物组织中的磷化合物。VII. 组织匀浆对二磷酸胞苷胆碱和卵磷脂的酶促合成
J Biol Chem. 1963 Nov;238:3565-71.
6
THE ALKALINE HYDROLYSIS OF THE ETHANOLAMINE PLASMALOGEN OF BRAIN TISSUE.脑组织乙醇胺缩醛磷脂的碱性水解
J Neurochem. 1963 Dec;10:941-5. doi: 10.1111/j.1471-4159.1963.tb11921.x.
7
ON THE SPECIFICITY OF CYTIDINE COENZYME IN THE INCORPORATION OF PHOSPHORYLCHOLINE INTO PHOSPHOLIPIDS BY TISSUE HOMOGENATES OF VARIOUS ANIMAL SPECIES.关于胞苷辅酶在不同动物物种组织匀浆将磷酸胆碱掺入磷脂过程中的特异性
Acta Biochim Pol. 1963;10:455-61.
8
Incorporation of 1-O-phosphoryl-2-dimethylaminoethanol and phosphorylcholine into the phospholipids of brain and liver dispersions.将1-O-磷酰基-2-二甲基氨基乙醇和磷酰胆碱掺入脑和肝分散液的磷脂中。
Nature. 1962 Nov 10;196:545-7. doi: 10.1038/196545a0.
9
The effects of 2-dimethylamino-ethanol on brain phospholipid metabolism.2-二甲基氨基乙醇对脑磷脂代谢的影响。
J Neurochem. 1962 May-Jun;9:253-63. doi: 10.1111/j.1471-4159.1962.tb09447.x.
10
A hydrolytic procedure for the identification and estimation of individual phospholipids in biological samples.一种用于鉴定和估算生物样品中单个磷脂的水解方法。
Biochem J. 1960 Apr;75(1):45-53. doi: 10.1042/bj0750045.