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噬菌体T4中的紫外线诱变。II. 突变损伤的光复活。

Ultraviolet mutagenesis in bacteriophage T4. II. Photoreversal of mutational lesions.

作者信息

Drake J W

出版信息

J Bacteriol. 1966 Jul;92(1):144-7. doi: 10.1128/jb.92.1.144-147.1966.

Abstract

Drake, John W. (University of Illinois, Urbana). Ultraviolet mutagenesis in bacteriophage T4. II. Photoreversal of mutational lesions. J. Bacteriol. 92:144-147. 1966.-T4r mutations were induced by ultraviolet irradiation of extracellular phage particles, using a phage mutant, v, which is particularly susceptible to photoreactivation. Most of the induced r mutations could be subsequently photoreversed intracellularly with white light. Ultraviolet irradiation induces both transitions and sign mutations, and both were susceptible to photoreversal. The results suggest that two very different types of mutational lesions may arise from a common type of photochemical lesion.

摘要

德雷克,约翰·W.(伊利诺伊大学厄巴纳分校)。噬菌体T4中的紫外线诱变。II.突变损伤的光复活。《细菌学杂志》92:144 - 147。1966年。——使用对光复活特别敏感的噬菌体突变体v,通过对细胞外噬菌体颗粒进行紫外线照射来诱导T4r突变。大多数诱导产生的r突变随后可在细胞内被白光光复活。紫外线照射会诱导转换突变和移码突变,且二者都易被光复活。结果表明,两种非常不同类型的突变损伤可能源于同一种光化学损伤。

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本文引用的文献

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Experiments on light-reactivation of ultra-violet inactivated bacteria.紫外线灭活细菌的光复活实验。
Proc Natl Acad Sci U S A. 1949 Oct;35(10):591-600. doi: 10.1073/pnas.35.10.591.
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The structure of the DNA-acridine complex.DNA-吖啶复合物的结构。
Proc Natl Acad Sci U S A. 1963 Jan 15;49(1):94-102. doi: 10.1073/pnas.49.1.94.

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