地塞米松对大鼠应激时血浆皮质酮反应的抑制作用。
Dexamethasone suppression of the plasma corticosterone response to stress in the rat.
作者信息
Donald R A
出版信息
J Physiol. 1966 Feb;182(3):603-11. doi: 10.1113/jphysiol.1966.sp007840.
Abstract
- The effect of dexamethasone on the plasma corticosterone response to heat-immobilization stress was investigated in male and female rats.2. The plasma corticosterone response of control rats to the type of stress described was 64 mug% (+/- 10.5 mug% standard deviation) in males, and 128 mug% in females.3. A straight line relation between the dose of dexamethasone and the log of the plasma corticosterone response was demonstrated in male rats. The slope of the dose-log response line was used to indicate the degree of suppression of the plasma corticosterone response to stress.4. The straight line relation did not hold for female rats, suggesting the presence of an additional factor or factors which influenced the plasma corticosterone levels.5. An exponential relation between the duration of dexamethasone administration and the slope of the dose-log response line was demonstrated, maximum suppression occurring after an infinite period of time. After 30 days, 95% maximum suppression occurred when the plasma corticosterone response was measured 8 hr after dexamethasone administration had ceased.
摘要
研究了地塞米松对雄性和雌性大鼠血浆皮质酮对应激热固定应激反应的影响。
对照大鼠对所述应激类型的血浆皮质酮反应，雄性为64微克%（±10.5微克%标准差），雌性为128微克%。
在雄性大鼠中证明了地塞米松剂量与血浆皮质酮反应对数之间呈直线关系。剂量-对数反应线的斜率用于表明对应激的血浆皮质酮反应的抑制程度。
雌性大鼠不存在直线关系，提示存在一个或多个影响血浆皮质酮水平的额外因素。
证明了地塞米松给药持续时间与剂量-对数反应线斜率之间呈指数关系，最大抑制在无限期后出现。30天后，当地塞米松给药停止8小时后测量血浆皮质酮反应时，出现95%的最大抑制。
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