Taché Y, Du Ruisseau P, Ducharme J R, Collu R
Horm Res. 1979;11(2):101-8. doi: 10.1159/000179045.
The influence of dexamethasone treatment on the basal values of corticosterone, GH, prolactin (PRL), LH and FSH, as well as on the adenohypophyseal hormone response to chronic stress was studied in female rats. Dexamethasone acetate (25 micrograms/100 b.w.), given by gavage twice daily for 10 days, decreased the resting plasma levels of corticosterone, GH, LH and PRL, whereas the FSH titers remained normal. The secretion of ACTH (evaluated indirectly through corticosterone concentrations) and of GH appeared to be most sensitive to the suppressive effect of dexamethasone. The same hormonal response pattern was induced by 8 h of daily immobilization for 10 days, except that ACTH release was enhanced and the plasma LH titers dropped more drastically. Dexamethasone administration in combination with restraint did not alter the characteristic hormonal profile of chronic stress, despite the fact that ACTH secretion was completely blocked. These data suggest that the inhibition of PRL, LH and GH secretion following severe, chronic stress is not causally related to the sustained elevation of plasma ACTH.
在雌性大鼠中研究了地塞米松治疗对皮质酮、生长激素（GH）、催乳素（PRL）、促黄体生成素（LH）和促卵泡生成素（FSH）基础值的影响，以及对腺垂体激素对慢性应激反应的影响。醋酸地塞米松（25微克/100体重），每日经口灌胃两次，持续10天，降低了皮质酮、GH、LH和PRL的静息血浆水平，而FSH效价保持正常。促肾上腺皮质激素（通过皮质酮浓度间接评估）和GH的分泌似乎对地塞米松的抑制作用最为敏感。每日固定8小时，持续10天，可诱导相同的激素反应模式，只是促肾上腺皮质激素释放增强，血浆LH效价下降更为明显。尽管促肾上腺皮质激素分泌被完全阻断，但地塞米松与束缚联合使用并未改变慢性应激的特征性激素谱。这些数据表明，严重慢性应激后PRL、LH和GH分泌的抑制与血浆促肾上腺皮质激素的持续升高没有因果关系。
