5-单环氧-β-胡萝卜素和5,6:5',6'-双环氧-β-胡萝卜素的代谢与生物活性
Metabolism and biologicalpotency of 5,-monoepoxy-beta-carotene and 5,6:5',6'-diepoxy-beta-carotene.
作者信息
Subbarayan C, Lkshmanan M R, Cama H R
出版信息
Biochem J. 1966 May;99(2):308-11. doi: 10.1042/bj0990308.
Abstract
- 5,6-Monoepoxy-beta-carotene and 5,6:5',6'-diepoxy-beta-carotene were partially converted into the furanoid forms during passage through the rat stomach. 2. The monoepoxide was converted into vitamin A in the small intestine and showed a biological potency 21% of that of beta-carotene. Neither beta-carotene nor 5,6-monoepoxyvitamin A was formed. 3. Intraperitoneal administration of the monoepoxide led to the accumulation of the unchanged compound in the liver and other tissues. 4. The diepoxide gave no beta-carotene or vitamin A or 5,6-monoepoxyvitamin A when given orally and showed no biological potency. 5. The significance of these results with special reference to the mechanism of formation of vitamin A from beta-carotene is discussed.
摘要
- 5,6-单环氧-β-胡萝卜素和5,6:5',6'-双环氧-β-胡萝卜素在通过大鼠胃部的过程中部分转化为呋喃型。2. 单环氧化物在小肠中转化为维生素A，其生物活性为β-胡萝卜素的21%。未形成β-胡萝卜素和5,6-单环氧维生素A。3. 腹腔注射单环氧化物导致未变化的化合物在肝脏和其他组织中积累。4. 双环氧化物口服时未产生β-胡萝卜素、维生素A或5,6-单环氧维生素A，且无生物活性。5. 讨论了这些结果对β-胡萝卜素形成维生素A机制的特殊意义。
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