犬关节中晶体诱导的炎症。II. 多形核白细胞的重要性。
Crystal-induced inflammation in canine joints. II. Importance of polymorphonuclear leukocytes.
作者信息
Phelps P, McCarty D J
出版信息
J Exp Med. 1966 Jul 1;124(1):115-26. doi: 10.1084/jem.124.1.115.
Abstract
In an experimental model, the polymorphonuclear leukocyte was found to be necessary to the inflammation induced by crystals. This conclusion is based on (a) the invariable migration of polymorphonuclear leukocytes into the synovial fluid of canine joints injected with urate crystals, (b) the experimental suppression of the synovitis by the depletion of polymorphonuclear leukocytes in animals treated with vinblastine, (c) the dependence of the degree of suppression on the degree of leukocyte mobilization into the joint space, and (d) the restoration of the inflammatory response in a leukopenic animal by perfusion with normal blood.
摘要
在一个实验模型中，发现多形核白细胞对于晶体诱导的炎症是必需的。这一结论基于以下几点：(a) 多形核白细胞始终会迁移到注射尿酸盐晶体的犬关节滑液中；(b) 用长春碱处理的动物中，多形核白细胞的消耗可实验性抑制滑膜炎；(c) 抑制程度取决于白细胞向关节腔的动员程度；(d) 通过灌注正常血液可使白细胞减少的动物恢复炎症反应。
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