犬关节晶体诱导的炎症。I. 宿主反应定量的实验模型。
Crystal-induced inflammation in canine joints. I. An experimental model with quantification of the host response.
作者信息
McCarty D J, Phelps P, Pyenson J
出版信息
J Exp Med. 1966 Jul 1;124(1):99-114. doi: 10.1084/jem.124.1.99.
Abstract
Injection of sodium urate or calcium pyrophosphate crystals into the stifle joints of anesthetized dogs almost invariably induced an acute exudative response. This response was quantified by serial measurements of intra-articular pressure, pH and leukocyte concentration. Pressure rose progressively and reflected intra-articular volume increase. The hydrogen ion concentration increased as the reaction progressed and correlated in a given exudate with the leukocyte concentration. Analysis of sequential physiologic and biochemical changes occurring in this model of crystal-induced inflammation may provide insight into the mechanisms of acute gouty arthritis in man.
摘要
向麻醉犬的膝关节内注射尿酸钠或焦磷酸钙晶体几乎总会引发急性渗出反应。通过对关节内压力、pH值和白细胞浓度进行系列测量来量化这种反应。压力逐渐升高，反映出关节内体积增加。随着反应的进行，氢离子浓度升高，并且在特定渗出液中与白细胞浓度相关。对这种晶体诱导炎症模型中发生的一系列生理和生化变化进行分析，可能有助于深入了解人类急性痛风性关节炎的发病机制。
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本文引用的文献
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INFLAMMATORY REACTION AFTER INTRASYNOVIAL INJECTION OF MICROCRYSTALLINE ADRENOCORTICOSTEROID ESTERS.关节腔内注射微晶状肾上腺皮质类固醇酯后的炎症反应
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PATHOGENESIS OF INFLAMMATION. I. THE PRODUCTION OF AN INFLAMMATORY SUBSTANCE FROM RABBIT GRANULOCYTES IN VITRO AND ITS RELATIONSHIP TO LEUCOCYTE PYROGEN.炎症的发病机制。一、兔粒细胞体外产生炎症物质及其与白细胞致热原的关系
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