McCarty D J, Phelps P, Pyenson J
J Exp Med. 1966 Jul 1;124(1):99-114. doi: 10.1084/jem.124.1.99.
Injection of sodium urate or calcium pyrophosphate crystals into the stifle joints of anesthetized dogs almost invariably induced an acute exudative response. This response was quantified by serial measurements of intra-articular pressure, pH and leukocyte concentration. Pressure rose progressively and reflected intra-articular volume increase. The hydrogen ion concentration increased as the reaction progressed and correlated in a given exudate with the leukocyte concentration. Analysis of sequential physiologic and biochemical changes occurring in this model of crystal-induced inflammation may provide insight into the mechanisms of acute gouty arthritis in man.
向麻醉犬的膝关节内注射尿酸钠或焦磷酸钙晶体几乎总会引发急性渗出反应。通过对关节内压力、pH值和白细胞浓度进行系列测量来量化这种反应。压力逐渐升高，反映出关节内体积增加。随着反应的进行，氢离子浓度升高，并且在特定渗出液中与白细胞浓度相关。对这种晶体诱导炎症模型中发生的一系列生理和生化变化进行分析，可能有助于深入了解人类急性痛风性关节炎的发病机制。
