Popa M, Florea I, Simionescu L, Dimitriu V
Endocrinologie. 1977 Oct-Dec;15(4):267-70.
Orally given 1-proline in high dosage (500 mg/kg b.w.) resulted in growth hormone (GH) release in 9 healthy, sexually immature children investigated (5 boys and 4 girls). A slight, unsignificant decrease of the mean prolactin level was also noted. Serum immunoreactive insulin (IRI), follicle-stimulating hormone (FSH) and luteinizing hormone (LH) concentrations in serum were not influenced. The possible use of proline loading in high dosage for the detection of GH deficiency especially in small children and in infants is suggested.
对9名健康的、性未成熟儿童（5名男孩和4名女孩）口服高剂量（500毫克/千克体重）的1-脯氨酸后，观察到生长激素（GH）释放。同时还注意到催乳素平均水平有轻微的、不显著的下降。血清免疫反应性胰岛素（IRI）、促卵泡激素（FSH）和黄体生成素（LH）的血清浓度未受影响。建议高剂量脯氨酸负荷试验可能用于检测生长激素缺乏，尤其是在幼儿和婴儿中。
