吸烟与血小板聚集
Cigarette smoking and platelet aggregation.
作者信息
Glynn M F, Mustard J F, Buchanan M R, Murphy E A
出版信息
Can Med Assoc J. 1966 Sep 10;95(11):549-53.
The influence of cigarette smoking on platelet aggregation was studied in habitual and non-habitual smokers. The results indicate that habitual smokers have a greater tendency to platelet aggregation than do non-habitual smokers. Acute effects of cigarette smoking were, however, not significant. The nucleotide content and the serotonin content of the platelets were analyzed. The adenosine nucleotide and serotonin contents were similar in smokers and non-smokers in the control state and neither showed significant changes on cigarette smoking. There were significant correlations between the control concentrations of the various nucleotides in both groups and there were even higher correlations after smoking. Platelet aggregation bore no demonstrable relationship to the nucleotide or serotonin contents of the platelet. We conclude that the long-term effect of smoking is probably more important than the acute effect.
在习惯性吸烟者和非习惯性吸烟者中研究了吸烟对血小板聚集的影响。结果表明，习惯性吸烟者比非习惯性吸烟者有更大的血小板聚集倾向。然而，吸烟的急性效应并不显著。分析了血小板的核苷酸含量和血清素含量。在对照状态下，吸烟者和不吸烟者的腺苷核苷酸和血清素含量相似，且吸烟后两者均未显示出显著变化。两组中各种核苷酸的对照浓度之间存在显著相关性，吸烟后相关性甚至更高。血小板聚集与血小板的核苷酸或血清素含量没有明显关系。我们得出结论，吸烟的长期效应可能比急性效应更重要。
Zotero 插件