Spinelli Sherry L, Lannan Katie L, Loelius Shannon G, Phipps Richard P
Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry , Rochester, New York.
Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry , Rochester, New York.
Appl In Vitro Toxicol. 2017 Mar 1;3(1):110-120. doi: 10.1089/aivt.2016.0034.
Human blood platelets are major hemostatic regulators in the circulation and important in the mediation of chronic inflammation and immunomodulation. They are key elements that promote cardiovascular pathogenesis that leads to atherosclerosis, thrombosis, myocardial infarction, and stroke. New information on tobacco use and platelet dysregulation shows that these highly understudied vascular cells are dysregulated by tobacco smoke. Thus, platelet function studies should be an important consideration for the evaluation of existing and next-generation tobacco and non-tobacco products. Novel approaches are being sought to investigate these products and their influence on platelet function. Platelets are ideally suited for product assessment, as robust and novel translational methods are available to assess platelet function. Furthermore, the use of human biological systems has the advantage that risk predictions will better reflect the human condition.
人类血小板是循环系统中主要的止血调节因子，在慢性炎症和免疫调节的介导中起重要作用。它们是促进心血管发病机制的关键因素，而心血管发病机制会导致动脉粥样硬化、血栓形成、心肌梗死和中风。关于烟草使用和血小板失调的新信息表明，这些研究严重不足的血管细胞会受到烟草烟雾的影响而失调。因此，血小板功能研究应成为评估现有及下一代烟草和非烟草产品的重要考量因素。目前正在寻求新的方法来研究这些产品及其对血小板功能的影响。血小板非常适合用于产品评估，因为有强大且新颖的转化方法可用于评估血小板功能。此外，使用人类生物系统具有风险预测能更好地反映人类状况的优势。
