Williams E D
J Clin Pathol. 1966 Mar;19(2):114-8. doi: 10.1136/jcp.19.2.114.
Thirty-one dog thyroid tumours and 28 spontaneous rat thyroid tumours were studied histologically and the findings compared with those of a study of 67 cases of medullary carcinoma of the human thyroid. Five of the dog tumours and 24 of the rat tumours were considered to belong to the same group of tumours as medullary carcinoma, a group characterized by solid sheets or lobules of uniform cells with granular cytoplasm and without papillary or follicular differentiation. In the rat tumours it was shown that the cell of origin was the parafollicular cell and not the thyroid follicle epithelial cell. It is suggested that medullary carcinoma is also derived from a parafollicular cell and that this origin would resolve the discrepancy between the relatively good prognosis and the apparently undifferentiated structure of this tumour. It is also concluded that the whole spectrum of clinical and pathological features of medullary carcinoma makes more sense if it is considered as a parafollicular cell tumour.
对31例犬甲状腺肿瘤和28例大鼠自发性甲状腺肿瘤进行了组织学研究，并将研究结果与67例人类甲状腺髓样癌的研究结果进行了比较。犬肿瘤中有5例、大鼠肿瘤中有24例被认为与髓样癌属于同一肿瘤组，该肿瘤组的特征是由均匀细胞组成的实性片层或小叶，细胞质呈颗粒状，无乳头或滤泡分化。在大鼠肿瘤中发现，起源细胞是滤泡旁细胞而非甲状腺滤泡上皮细胞。有人提出，髓样癌也起源于滤泡旁细胞，这种起源将解释该肿瘤相对较好的预后与其明显未分化结构之间的差异。还得出结论，如果将髓样癌视为滤泡旁细胞瘤，那么其整个临床和病理特征谱就更说得通了。
