Dominic C J
Science. 1966 Jun 24;152(3730):1764-5. doi: 10.1126/science.152.3730.1764.
Failure of pregnancy in newly mated female mice exposed to fresh urine from alien males is prevented by administration of reserpine, at 6.25 micrograms per day per female, on days 1 to 5 post coitum-that is, throughout the period of exposure to male urine and for 2 more days. Since reserpine is known to suppress the inhibitory center in the hypothalamus controlling the release of prolactin, inhibition by reserpine of the blockage of pregnancy provides a strong direct indication of hypothalamic mediation in the male-induced failure of pregnancy in mice.
在交配后的第1至5天，即整个接触雄性尿液的期间以及之后2天，每天给每只雌性小鼠注射6.25微克利血平，可防止新交配的雌性小鼠接触外来雄性的新鲜尿液后出现妊娠失败的情况。由于已知利血平会抑制下丘脑控制催乳素释放的抑制中枢，利血平对妊娠阻断的抑制作用有力地直接表明，下丘脑在雄性诱导的小鼠妊娠失败中起介导作用。
